AHA Branded Blue Presentation

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American Heart AssociationTexas Affiliate
Brent Fields Vice President Research
Administration State Health Alliances
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Research AHA Top Priority
The AHA believes that learning more about the 1
and 3 killers in America is one of the best ways
to accomplish our mission Impact Goal By 2010,
we will reduce coronary heart disease, stroke and
risk by 25 percent.
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• The AHAs commitment to research is reflected in
  our strategic plan
• Increasing the capacity of the research community
  to generate the highest quality research
• Identifying critical research agendas and
  increasing the understanding of specific
  cardiovascular issues.

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Research ExpenseforMajor National Health
Agencies 2004
A American Cancer Society B Alzheimers
Association C American Diabetes Association D
National Multiple Sclerosis Society E March of
Dimes F Muscular Dystrophy Association G
Juvenile Diabetes Association H American Heart
Association
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AHAs 2004-05 EXPENDITURES
AHA National Budget Expenditures
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How each dollar is spent
75
25
Donor Dollar
National Center
Texas Affiliate
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Research Allocation
13.5
28.5
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Nobel Prize Recipients funded by AHA

• 1937 Dr. Albert Szent-Gyorgyi
• 1971 Dr. Earl Sutherland
• 1985 Dr. Joseph Goldstein
• 1985 Dr. Michael Brown
• 1992 Dr. Edwin Krebs
• 1998 Dr. Robert Furchgott
• 2003 Dr. Peter Agre

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Milestones

• 1956 - Dr. Ancel Keys, supported by funding from
  the Minnesota Affiliate, first links dietary fat
  with
• cholesterol. This discovery spurs the AHA to
  assume a leading role in urging Americans to
• change their eating habits.
• 1956 - Dr. Paul Zoll, aided by the Massachusetts
  Affiliate, publishes the first report of the
  successful
• ending of ventricular fibrillation in humans
  by externally applied countershock.
• 1957 - Dr. William Wierich, assisted by support
  from the Minnesota Affiliate and joined by Drs.
• Vincent Gott and Walter Lillehei, implants
  the first externally powered pacemaker in a
  patient
• with a surgical heart blockage.
• 1960 - Dr. Albert Starr performs the first
  long-term successful mitral valve replacement
  with a caged
• ball valve, ushering in a new era of valve
  replacement. He was supported in developing the
• artificial heart valve by the Oregon
  Affiliate and assisted by engineer Lowell
  Edwards.
• 1961 - Dr. Julius Jacobsen, with funding from the
  Vermont Affiliate, begins performing surgery with

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Texas Research Statistics

• FY 06-07 there are currently 154 Texas
  Researchers funded by the AHA
• (TX Affiliate 96 National 58)
• FY 06-07 total amount funded 9,152,708
  
• (TX Affiliate 4,974,265 National
  4,178,443)
• 2000-2008 total funding 67,993,077
• (TX Affiliate 36,611,162 National
  31,381,915)
• Currently 11 cities and 22 institutions are
  represented by funded researchers in Texas
• 100 Texas researchers participated in our TXA
  Peer Review in
• 2006
• There are currently 15 Research Allocations and
• Advisory Committee Members (RAAC)

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Galveston Statistics

• University of Texas Medical Branch
• TXA Applications received/funded for the 2006
  cycle 13/2
• TXA Applications received/funded 2000-2006
  100/19
• 7 Active Researchers TXA - 6 National 1
• 410,500 in Active AHA grants (FY 06-07 actual
  spent)
• (TXA - 345,500 National - 65,000)
• 3,728,376 in AHA funding (2000-2008 allocated)
• (TXA - 2,355,981 National - 1,372,395)
• Current Research Allocations Advisory Committee
  Members
• Paul Boor, MD Professor, Dept. of Pathology

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Galveston Statistics

• University of Texas Medical Branch
• Texas Affiliate Currently Funded Researchers
• 2005-07 Kishor Bhakat, PhD
• Beginning Grant-in-Aid
• Role of Human AP-endonuclease (APT1/Ref-1) in
  Regulation of Blood Pressure
• 2005-07 Perenlei Enkhbaatar, MD, PhD
• Beginning Grant-in-Aid
• Role of nitric oxide in pathogenesis of
  cardiopulmonary derangements in sepsis induced
  by smoke inhalation and pnemonia
• 2005-07 Luis Ruess, MD
• Grant-in-Aid
• Architecture of the Pore of Connexin43 Channels
  and Hemichannels
• 2005-07 Bruns Watts lll, PhD
• Beginning Grant in Aid
• Regulation of Renal Transport by Neurotropins

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Galveston Statistics

• University of Texas Medical Branch
• National Center Currently Funded Researchers
• 2006-09 Sanjeev Choudhary, PhD
• Scientist Development Grant
• Novel Role of the NF-kB inducing kinase in
  Respiratory Syncytial Virus infection

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Research Focus

• Training and career development of beginning
  scientists
• Support of cutting edge basic and clinical
  science

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What Kinds of Research Do We Support?
The AHA supports research that is broadly
related to the cardiovascular area and stroke.
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SCIENCE AREAS

• Basic Cell and Molecular Biology
• Behavior Science, Epidemiology Prevention
• Bioengineering Biotechnology
• Brain
• Cardiac Biology/Regulation
• Cardiac Electrophysiology Arrhythmias/Regulation
  
• Cardiorenal
• Cardiovascular Development
• Cell Transort, Physiology Metabolism
• Immunology and Microbiology
• Liporproteins, Lipid Metabolism Nutrition
• Lung, Respiration Resuscitation

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SCIENCE AREAS

• Molecular Signaling
• Radiology Imaging
• Surgery
• Thrombosis
• Vascular Biology Blood Pressure/Regulation
• Vascular Wall Biology

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Programs Offered by AHA National Center

• Scientist Development Grant
• January and July Application Deadline for
  January and July activation
• Fellow to Faculty Grant
• January and July Application Deadline for
  January and July activation
• Established Investigator Award
• July Application Deadline for January
  activation

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Programs Offered by the Texas Affiliate

• Postdoctoral Fellowship
• January application deadline for July
  activation
• Beginning Grant-in-Aid
• January application deadline for July
  activation
• Grant-in-Aid
• January application deadline for July
  activation

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Postdoctoral FellowshipTo provide stipend
support to help trainees initiate careers in
cardiovascular and stroke research, and further
research training while obtaining significant
research results. (2006 Success Rate for this
Program 51 Applications, 8 funded, 16 funded)

• Deadline January 4, 2007
• Award 30,000 - 46,000 stipend, depending on
  years of training or experience,
• plus annual 3,000 departmental allowance.
•  Term 1 or 2 years. May apply for competitive
  one-year award.
• Full-time research effort and sincere interest in
  pursuing a career in
• cardiovascular related research expected.
• Applicant must hold a doctoral degree and have
  less than 6 years of post doctoral
• research training and experience at award
  activation (July 1, 2007).
• Support is limited to work within non-profit
  institutions in Texas.
• Institutional supplementation permissible under
  certain conditions.
• An investigator may sponsor no more than two
  Affiliate Post Doctoral Fellows at any
• one time. Any application for a new award that
  would exceed this limit will not be reviewed.
• Each of the following criteria will be
  considered
• The applicant
• The sponsors qualifications
• The environment and training program resources
• The specific research project

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Beginning Grant-in-aidTo Promote the
Independent Status of Promising Beginning
Scientists by Supporting High Quality,
Well-defined Research Projects in the
Cardiovascular Area, Including Stroke. (2006
Success Rate for this Program 90 applications,
21 funded, 23 funded)

• Deadline January 4, 2007
• Award 65,000 per year maximum, including 10
  overhead. Up to 15,000 annually for PI
• salary, including fringe benefits.
• Term 2 years. Competitive renewal is possible
  for up to four years of support.
• Applicants must have
• an MD, PhD, DO, DVM, or equivalent doctoral
  degree.
• A faculty appointment or equivalent academic or
  research track position, up to
• and including a rank of assistant professor, by
  the time of award activation (July 1, 2007).
• The applicant must meet institutional
  requirements for submission of an extramural,
  peer
• reviewed grant proposal.
• No more than 7 years of active faculty
  appointment prior to award activation (July 1,
  2007).
• No more than 100,000 of all extramural grant
  support per year, excluding principal
• investigator and collaborating investigators
  salaries, fringe, and intramural funding
• Each of the following criteria will be
  considered
• Evidence the award will promote the independent
  status of the applicant
• Scientific excellence of the proposal

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Grant-in-aidTo Support the Most Innovative and
Meritorious Research Projects FromIndependent
Investigators in the Cardiovascular Area,
Including Stroke.(2006 Success Rate for this
Program 78 applications, 16 funded, 21 funded)

• Deadline January 4, 2007
• Award 65,000 per year maximum, including 10
  overhead. Up to 15,000
• annually for PI salary, including fringe
  benefits.
•  Term 2 years. (One year requests are
  exceptional, but allowed)
• Continuous support of any one investigator is
  limited to 4 years
• Applicants must have
• An MD, PhD, DO, DVM, or equivalent doctoral
  degree
• A faculty appointment or equivalent academic or
  research track position, up to and including a
  rank of
• assistant professor, by the time of award
  activation (July 1, 2007). The applicant must
  meet institutional
• requirements for submission of an extramural,
  peer reviewed grant proposal.
• No more than 200,000 of all extramural grant
  support per year, excluding principal
  investigator and
• collaborating investigators salaries, fringe,
  and intramural funding
• Grants will not be awarded to supplement or
  duplicate any work that is being supported by
  other
• funding agencies. The only exceptions are
  career development awards.
• The scientific merit with emphasis on the
  innovative nature of the proposal is the most
  important
• factor.
• Other Criteria include

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2006Success Rate Texas Affiliate
Awards Funded 45 (5,314,314) 11 cities 18
institutions (New 2006 Awards) (RAAC allocations
from May, 2006 Committee Meeting)
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2006 Success Rate National Center
Awards Funded 22 (7,500,000) 7 cities 7
institutions (National allocations to Texas for
January July 2006)
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Peer Review Structure
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Peer Review Study Groups2006-07
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Life Cycle of a Research Application
Hmm
Yea!
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The ProcessTexas Affiliate
January
February
March

• Application Deadline
• Applications assigned to Committees

• Committee Chairs review assignments
• Committee Chairs finalize assignments
• Reviewers input preference

• Paper copies are sent to reviewers

May
April
July

• Research Committees meet
• Award Notification

• Peer Review Committee meets

• Award activation

• September online applications are available
• October institutional tour to promote program

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Other AHA Scientific Products

• AHA Professional Membership/Scientific Council
• Scientific Statements/Guidelines
• Scientific Sessions, Conferences and Workshops
• AHA Scientific Journals
• My.Americanheart.org

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• QUESTIONS?
• For Assistance Contact
• Brent Fields
• VP, Research Administration
• 512-433-7103 Phone
• Rhonda Jennings
• Administrative Assistant, Research Administration
• 512-433-7108 Phone
• 512-433-7260 fax
• texresearch_at_heart.org