The Changing Landscape of Medical Research

1
The Changing Landscape of Medical Research Drug
Development

• A UK Pharma Perspective

2
The global challenge in healthcare has never been
greater

• Ageing population long term disease management
• Fast paced, fast food societies stress,
  addiction, obesity
• Environment is evolving allergens, pollutants,
  global warming
• Prevalence of drug resistant and new infections
• Preventative medicine
• Unmet medical need in a global landscape

3
The Pharmaceutical sector in the UK
Ø      The pharmaceutical industry is the biggest
sector investor in RD in the UK accounting for
around 25 of total investment by business,
valued at 3.3bn, in 2005 Ø      The UK industry
has discovered and developed more leading
medicines than any other country apart from the
USA, and as much as the rest of Europe
combined Ø      The Industry accounts for around
0.6 of UK GDP, and the UK is one of the world's
largest exporters of pharmaceuticals by value.
Industry exports in 2007 were 14.6 billion and
created a trade surplus of 4.3 billion Ø     
UK domestic market accounts for 4 of world
consumption. Larger markets are USA (43), Japan
(12), Germany (5), and France (5) Ø      In
the UK, the industry employs around 73,000 people
with about 27,000 in research development and
generates another 250,000 jobs in related
industries.
4
The traditional pharma business model is
changing from this
Today

• 1.1 billion USD to bring one drug from concept
  to market
• 12.5 years to develop a new medicine
• One in 5000 new chemical compounds make it to
  market
• Society expects access to safe and effective
  medicines with no side-effects
• 80 drugs fail leaving 20 to fund the RD engine

5
to this

• Tomorrow
• In RD we need to be faster, reduce attrition
  and contain costs

• We need to work with healthcare providers to
  ensure that the patient gets the right drug at
  the right dose at the right time

This vision is dependent on our ability to
innovate both in our science and in our ways of
working
6
Where can emerging science make an impact?
We cannot do this alone!
Cell-based novel disease models
Disease prevention vaccines
7
Collaboration is an essential element for future
success
Licensedfrom Small Pharma/Biotech
Licensedfrom Academia
Alliances
Discovered In-House
Partnerships
Collaborations
Drug Pipeline
P R O D U C T S
8
Turning our vision into reality
There are a whole spectrum of new challenges
which depend on the ability of governments,
academic scientists, pharma and biotech companies
to all work together in an innovative way.
Enabling this vision will require-

• A vibrant scientific community interested in
  solving these problems and equipped with the
  skills to do so

• A solid ethical framework to ensure that new and
  sometimes sensitive areas of science meet public
  expectations

9
Why should AZ invest in UK science skills?

• Share our passion for science

• Second reason - Difficult to find skills in the
  UK-
• In vivo sciences
• Toxicology
• Pathology
• PK/PD modelling
• Maths aspects of biology, preclinical statistics
• Clinical pharmacology, translational medicine

• Third reason concerns over recruiting 1st
  degree graduates since their education and
  training is highly variable, particular concerns
  are-
• Lack of maths skills
• Lack of hands-on practical experience in the
  laboratory
• Variability in subject discipline

10
Some examples of what we can do to make a
difference

• Working in schools
• Science Engineering Ambassadors bring science
  into the classroom
• Project Enthuse offers every science teacher in
  the UK training at the National Science Learning
  Centre
• AstraZeneca Science Teaching Trust

• Working with other UK pharma
• Influence government through the ABPI skills
  report
• Help shape a Science Diploma as an alternative
  route into science
• Work through SEMTA to help implement the
  Bioscience Sector Skills Agreement
• Influence universities on maths, practical skills
  and course content

• Working with UK science-based industry
• Raise awareness that science skills can lead to a
  wide range of careers options
• Influence government on STEM education at every
  level
• Share our passion for science

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Our priorities - working with government

• Increase number of young people studying science
• Enhance teaching of science and maths in schools
  for all

• Restore rigour in key scientific subjects at
  undergraduate level
• Ensure focus on biomedical researchs traditional
  and emerging skills needs
• Prioritise skill areas, to take forward
  initiatives that are sustainable

12
Our priorities - working with academia

• Share agendas, priorities and resources
• Participate in teaching in universities and
  teaching hospitals
• Influence university course content, in
  partnership with academic leaders in critical
  skill areas
• Encourage sandwich students and other industrial
  placements
• Foster greater interchange of post-graduates
  fellowships, secondments dual appointments

Partners in Science
13
A robust and transparent ethical framework for
the governance of our science

• In AZ we have a mandatory code of conduct
  underpinned by training for all staff
• Supporting this we have a new series of global
  policies which also apply to all AZ staff, and
  which will be placed in the public arena.
  Included in this series is a new Bioethics policy
  which brings together a comprehensive view of the
  ethical governance of our science.

14
As part of the UK Science Community
Private Companies can Deliver

• Champions for UK science skills for the future
• Collaborators on relevant science for today
• Influencing strategic science for the future
• A transparent approach to the ethical governance
  of our science