Endometrial Committee

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Endometrial Committee

• David Scott Miller, M.D., F.A.C.O.G., F.A.C.S.
• Director and Dallas Foundation Chair in
  Gynecologic Oncology
• Professor of Obstetrics Gynecology
• University of Texas Southwestern Medical Center
• Dallas, Texas, U.S.A.

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PROPOSED GCIG STUDIESOther

• GTN
• GOG-0242 A Phase II Study to Determine the
  Response to Second Curettage as Initial
  Management for Persistent Low Risk,
  Non-Metastatic Gestational Trophoblastic
  Neoplasia
• Carcinosarcoma
• GOG UC-0701 A Randomized Phase III trial of
  Carboplatin Plus Paclitaxel vs. Ifosfamide Plus
  Paclitaxel in Chemotherapy Naïve Patients with
  Newly Diagnosed Stage I-IV, Persistent or
  Recurrent Carcinosarcoma (Mixed Mesodermal
  Tumors) of the Uterus

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Resected Endometrial

• GOG-0249 A Phase III Trial of Pelvic Radiation
  Therapy versus Vaginal Cuff Brachytherapy
  Followed by Paclitaxel/Carboplatin Chemotherapy
  in Patients with High Risk, Early Stage
  Endometrial Cancer
• RTOG
• PORTEC 3 Randomized Phase III Trial Comparing
  Concurrent Chemoradiation and Adjuvant
  Chemotherapy with Pelvic Radiation Alone in High
  Risk and Advanced Stage Endometrial Carcinoma
• NCRI

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Resected Endometrial

• EORTC? The role of adjuvant chemotherapy in
  surgical stage I-II serous or clear cell
  endometrial carcinoma a randomized phase III
  trial
• NSGO GCIG Phase III trial on adjuvant therapy
  in radically operated endometrial cancer patients
  with high risk for micro-metastatic disease
  chemotherapy radiotherapy (CTRT) versus
  chemotherapy (CT
• MITO New adjuvant trial comparing sequential CT
  RT, as standard arm, versus CT only in FIGO Stage
  III

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Resected Endometrial

• GOG UC0704 A Randomized Phase III Trial of
  Cisplatin and Tumor Volume Directed Irradiation
  Followed by Carboplatin and Paclitaxel vs.
  Carboplatin and Paclitaxel for Optimally
  Debulked, Advanced Endometrial Cancer
• RTOG

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Resected Endometrial

• GOG-0249 A Phase III Trial of Pelvic Radiation
  Therapy versus Vaginal Cuff Brachytherapy
  Followed by Paclitaxel/Carboplatin Chemotherapy
  in Patients with High Risk, Early Stage
  Endometrial Cancer
• RTOG
• PORTEC 3 Randomized Phase III Trial Comparing
  Concurrent Chemoradiation and Adjuvant
  Chemotherapy with Pelvic Radiation Alone in High
  Risk and Advanced Stage Endometrial Carcinoma
• NCRI

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Pelvic Recurrence

• GOG-0238 A Randomized Trial of Pelvic
  Irradiation with or without Concurrent Weekly
  Cisplatin in Patients with Pelvic-only Recurrence
  of Carcinoma of the Uterine Corpus
• RTOG, NCRI

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Advanced/Recurrent

• NCIC Deforolimus vs. hormones phase III RCT in
  women with metastatic/recurrent endometrial
  cancer
• ACRIN, AGO-AUST, AGO-OVAR, ANZOG, EORTC, GEICO,
  JGOG, MITO, NCRI, NSGO