e

1
Virtual Intl Molecular Biology Laboratory (eIMBL)
Functions and Operations
Australia China Hong Kong India Indonesia Japan Ko
rea Hong Kong Malaysia New Zealand Philippines Sin
gapore Taiwan Thailand Vietnam Israel
electronic International Molecular
Biology Laboratory
e I M B L
2
electronic International Molecular Biology
Laboratory
Definition of eIMBL
- A state-of-the-art web-based molecular
biological laboratory network
- linking leading scientists, institutions,
entrepreneurs investors and policy makers -
to capitalize on the knowledge and expertise base
of participating laboratories - across the
Asia-Pacific region
3
electronic International Molecular Biology
Laboratory
Status
A unique International Virtual Laboratory
Network - International in status,
non-political in management, staffing and
operation - Shall be organized exclusively for
scientific, developmental and educational
purposes - Shall operate as a non-profit
organization under the aegis of the
Asia-Pacific International Molecular Biology
Network (A-IMBN)
4
A-IMBN

• Established in 1997 to promote development of
  molecular
• biology and biotechnology throughout the
  Asia-Pacific region
• Consists of 300 leading scientists from 16
  participating economies
• and 15 Supporting Institutes
• Australia, China, Chinese Taipei, Hong
  Kong, India, Indonesia, Israel,
• Japan, Korea, Malaysia, New Zealand,
  Pakistan, the Philippines,
• Singapore, Thailand, Vietnam
• Possesses a world-class International Advisory
  Board, and works
• in close consultation with EMBO, ICGEB
• Recognized as a priority APEC (Asia Pacific
  Economic Cooperation)
• initiative since 1998
• Funds come from private and government sources
  and the financial
• accounts are managed by a non-profit
  organization in SF

5
What A-IMBN does

• Sponsors annual conferences, training courses,
  fellowship programs, practical workshops
  throughout the region
• 1998 Seoul 1999 Singapore 2000
  Brisbane 2001 Taipei 2002 Shanghai
• 2003 Tokyo 2004 Bangkok 2005 Ho Chi
  Minh City 2006 Kuala Lumpur
• Promotes RD innovation and dissemination of
  knowledge in molecular biology and directly
  related areas of science and technology
• Planning, development and coordination of
  multi-center, multi-investigator collaborative
  research projects
• Fully committed to supporting eIMBL project in
  manpower
• and finance

6
electronic International Molecular Biology
Laboratory
A Brief History of eIMBL

• A-IMBN decided to found eIMBL at the Governing
  Council
• Meeting (Tokyo, November 2003)
• The proposal to establish eIMBL received broad
  base support
• at the APEC ST Ministers Meeting
• (Christchurch, NZ, March 2004)
• The eIMBL proposal approved unanimously at the
  A-IMBN
• GC Meeting (Bangkok, November 2004)
• Establishment of eIMBL was endorsed at the APEC
  ISTWG
• Meeting (GwangJu, March 2005)
• The official launching of eIMBL in conjunction
  with the APEC
• Summit Meeting (Seoul, November 17, 2005)

7
electronic International Molecular Biology
Laboratory
The Communiqué at 4th APEC ST Ministers
Meeting (Christchurch N.Z., March 2004)
Ministers recognized the importance across
a wide range of sectors of exiting networks,
noting the work of the A-IMBN .as examples,
and the proposed initiatives of eIMBL for
furthering advancements in these areas.
8
electronic International Molecular Biology
Laboratory
Functions of eIMBL
eIMBL
Research Activity
Scientific Networking
Database
Symposium and Workshop
Training Courses
Membership and Personnel Exchange
ePublication of international journal
Head of Unit Lab
Individual labs
9
electronic International Molecular Biology
Laboratory
Unit Laboratory Key Functions

• Networking individual labs of related research
  field
• and coordinate their research activities
• Provide scientific information/database through
  its
• official homepage, www.eimbl.org
• Organize symposium, workshop and training
  courses
• annually for participating laboratories

Two Unit labs Systems Biology and DNA
Replication were established during the
first year of operation
10
electronic International Molecular Biology
Laboratory
Systems Biology (Unit Lab)

• Systems biology is an effort seeking
  system-level understanding of
• biological phenomena of varying orders such
  as molecules, cells,
• organs, individuals, or even echo-systems.
• Participating Laboratories
• - Head of the eIMBL-Systems Biology Laboratory
  Dr. Do Han Kim (Gwangju Institute of Science and
  Technology, Korea)
• - Core members
• Dr. Kwang-Hyun Cho (Seoul National University,
  Korea) Dr. Sang Yup Lee (Korea Advanced
  Institute of Science and Technology, Korea)
  Dr. Young Sook Yoo (Korea Institute of Science
  and Technology, Korea) Dr. Shui-Tein Chen
  (Academia Sinica, Taiwan) Dr. Eytan Domany
  (Weizmann Institute of Science, Israel) Dr.
  Upinder S. Bhalla (The National Centre for
  Biological Sciences, India) Dr. Masaru Tomita
  (Keio University, Japan) Dr. Peter J. Hunter
  (The University of Auckland, New Zealand) Dr.
  Gang Pei (Shanghai Institute for Biological
  Sciences, China) Dr. Gianhua Liu (Genome
  Institute of Singapore, Singapore)
• Dr. Siegfried Neumann (Merck, Darmstadt,
  Germany)

11
electronic International Molecular Biology
Laboratory
DNA Replication (Unit Lab)

• DNA replication is initiated at a region on a
  chromosome called the origin of replication. The
  question how replication origins are organized to
  replicate the complex genome of eukaryotes is of
  general interest.
• Participating Laboratories
• - Head of the eIMBL-DNA Replication
  Laboratory
• Dr. Hisao Masai (Tokyo Metropolitan Inst.
  of Medical Science, Japan)
• - Core members
• Dr. Arturo Falaschi (ICGEB, Italy)
• Dr. Tsutomu Katayama (Kyushu Univ., Japan)
• Dr. Akira Shinohara (Osaka Univ., Japan)
• Dr. Chun Liang (Hong Kong University of Science
  and Technology, Hong Kong)
• Dr. Yoshi Watanabe (Tokyo Univ., Japan)
• Dr. Zuxun Gong (Inst. of Molecular and Cell
  Biology, China)
• Dr. Deog Su Hwang (Seoul National Univ., Korea)
• Dr. Yeonsoo Seo (KAIST, Korea)
• Dr. Byrappa Venkatesh (Inst. of Molecular and
  Cell Biology, Singapore)
• Dr. Jun Kyu Lee (Seoul National Univ., Korea)
• Dr. Akio Sugino (Osaka Univ., Japan)

12
electronic International Molecular Biology
Laboratory
Genomic Medicine (Unit Lab)

• Promotion of international collaborative research
  for the illumination of disease mechanism through
  genome-wide studies and the development of
  therapeutics thereon
• Participating Laboratories
• - Head of the eIMBL-Genomic Medicine
  Laboratory
• Dr. James Shen (Institute of Molecular
  Biology, Academia Sinica, Taiwan)
• - Core members
• Dr. Yusuke Nakamura (Univ. of Tokyo, Japan)
• Dr. Hiroyuki Aburatani (Univ. of Tokyo, Japan)
• Dr. Kumiko Tei (Univ. of Toky, Japan)
• Dr. Pak Sham (Univ. of Hong Kong, Hong Kong)
• Dr. Y.-T. Chen (Taiwan)
• Dr. Jianjun Liu (Genomic Institute of Singapore,
  Singapore)
• Dr. Hyung-Rae Kim (Korea Centers for Disease
  Control and Prevention, Korea)
• Dr. Sangsoo Kim (Soongsil Univ., Korea)

13
eIMBL Unit Lab (Molecular Oriental Medicine)
A-IMBN/eIMBL BioMax
Member Labs
Molecular Oriental Medicine IBCB, SIBS, Shanghai
Bangkok Jakarta HCM city Johor, KL India
Tokyo Lab
Taipei (NTU)
Seoul (IMBG, SNU)
14
eIMBL Unit Lab (Infectious Disease)
A-IMBN/eIMBL IVI, Seoul
Member Labs
Infectious Disease ICGEB, New Delhi
Bangkok Jakarta HCM city Johor, KL India
Tokyo Lab
Taipei (NTU)
Shanghai Lab (IBCB, SIBS)
15
Research interface of eIMBL labs www.eimbl.org
electronic International Molecular Biology
Laboratory
16
electronic International Molecular Biology
Laboratory
Structure of eIMBL System
Network
Advanced Network enabled IP
multicast
Advanced Network ( KOREN / KREONET)
Network
eIMBL system
Video Conference
Public space
Messenger
Cyber_ lab
Video/ voice
message
Html
Jsp
Java Bean
Access Grid
Web Server / Tomcat
Messenger Server
video
voice
control
Messenger Database
eIMBL Database
UNIX
Window NT
Windows, Linux
17
electronic International Molecular Biology
Laboratory
Goals and Benefits of Unit Labs

• Share research equipment, materials, know-how,
• and laboratory personnel
• Conduct real-time peer discussion and analysis
• of experimental results among laboratories
• participating the Unit Lab
• Increase chances and opportunities of
  international
• research collaboration

Each eIMBL lab will benefit from the
cost-effective, efficient nature of this new
research environment to enhance scientific
achievements
18
electronic International Molecular Biology
Laboratory
Activities for Scientific Networking
- Organization of training programs and
practical courses in cooperation with the
EMBO, ICCGEB and other international
collaborators - Organization of online
education and online discussion forum
focused on problems areas of concern - Career
development resources - including recruitment
and placement support - Publication of a
leading electronic international journal in
collaboration with the Nature Publishing Group
19
electronic International Molecular Biology
Laboratory
Publication of e-Journal

• - A website highlighting the best research in
  molecular and cell
• biology in the Asia-Pacific
• Consist of Short highlight articles written by
  NPG editors describing
• hot research papers recently published by
  researchers in the
• A-IMBN/eIMBL network and the Asia-Pacific
  region
• - To build up awareness and usage of the website,
  it will be open
• to access to the world at least in the early
  phase
• - As the website becomes established, it will
  move towards
• publishing its own primary peer reviewed
  research with paid
• access to the content
• - A dummy website using actual example of hot
  papers published
• by A-IMBN/eIMBL institutes was opened in
  April 2006

20
electronic International Molecular Biology
Laboratory
Structure of eIMBL
Executive Director
Advisory Board
Collaborating Institute
International Supporting groups
Secretariat office Managing Director Dr. SangSoo
Kim
Div. of Intl Collaboration
Div. of Academic affairs
Div. of Information
Div. of ePublication
Laboratories

• Symposium
• Workshop
• Training Course

• APEC
• EMBC
• ICGEB

• Database
• Membership
• Placement

• Intl Journal

DNA Replication Lab (Center Tokyo, Japan)
System Biology Lab (Center Gwangju, Korea)
Genomic Medince Lab (Center Taipei, Taiwan)
21
electronic International Molecular Biology
Laboratory
Financing

• The government of Korea has committed to
  serving as Foundation
• Sponsor by providing the initial cost for
  establishment and
• implementation of eIMBL
• A-IMBN affirms its commitment to making
  significant, continued
• contributions annually to support eIMBL
• eIMBL welcomes and will recognize other
  interested governments,
• institutions, corporations, foundations and
  individuals who provide
• financial support for its program as
  sponsors
• Sponsors are free to choose specific
  programmatic initiatives that
• they wish to finance, or to provide general
  core budgetary support
• for eIMBL

22
electronic International Molecular Biology
Laboratory
Summary
eIMBL will provide a web-based platform to
address and solve priority concerns of
researchers through networking the excellent
bioscience laboratories in the Asia-Pacific

• Facilitates the international flow of
  information and scientists
• among Asian-Pacific Rim
• Promotes the collaborative researches and
  cooperative
• actions among participating laboratories/instit
  utes
• Enhances the biotechnology capability of APEC
  economies