FoodEnergy Regulation

1
Food/Energy Regulation

• Food
• Nutrients
• Amino acids
• Minerals
• Energy
• Carbohydrates
• GLUCOSE
• Fats
• kCal

2
Insulin

• Insulin
• Made/released by pancreas
• Glycogen - storage

3
Insulin

• Sequence of Events
• Cephalic phase
• Digestive phase
• Aborptive phase
• Diabetes mellitus
• Type I
• Type II

4
Control of Hunger

• Insulin (via Liver)
• Hypothalamus
• Ventromedial hypothalamus (VMH)
• Satiety?
• Lateral hypothalamus (LH)
• Hunger?

5
Control of Hunger

• Arcuate nucleus
• Responds to
• Insulin
• Pancreas
• Leptin
• Fat cells
• Ghrelin
• Stomach
• PYY3-36
• Small and large intestine

6
Control of Hunger

• Neurons
• Neuropeptide Y (NPY)/ Agouti-related peptide
  (AgRP)
• Pro-opiomelanocortin (POMC)/ Cocaine and
  amphetamine regulated transcript (CART)