Sickle Cell Disease

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Sickle Cell Disease

• Avital Howard

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Sickle Cell disease

• Also referred to as Sickle Cell Anemia

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Mode of Inheritance

• People who have Sickle Cell Disease have a
  mutation in a gene (Hemoglobin gene) on
  Chromosome 11.
• Inherited in an autosomal recessive pattern.
• About 1 out of every 500 African American babies
  born in the United States has Sickle cell anemia.

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Punnett Square

• Mom
• Homozygous
• Recessive
• Dad
• Homozygous dominant

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Symptoms of the Disorder and Detection

• If you have Sickle Cell Disease your oxygen is
  prevented from reaching your spleen, liver,
  kidneys, lungs, heart, or other organs, causing a
  lot of damage. Your cells from organs will begin
  to die if you dont have enough oxygen.

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Detection

• Most doctors screen newborns for sickle cell
  disease by doing a blood test.
• If the disease is not detected at birth then you
  can use a blood sample in a test called
  hemoglobin electrophesis.

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Prognosis

• Patients who have sickle cell disease have a
  survival rate of 85.6 percent at 18 years old
• Patients with less severe forms of sickle cell
  disease had a survival rate of 97.4 percent at
  18.
• Penicillin Babies and young children with the
  disease must take this medicine daily to prevent
  potentially deadly infections.
• Folic acid Some patients might take this
  medicine to help build new red blood cells.

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Genetic Counseling

• A genetic counselor would be able to look at your
  genetic material and let you know if you might
  have the disease, and if you do what the chances
  are of you having a child with the disease.

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Graphics
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Additional Interesting Facts

• Unlike normal red blood cells, which can live for
  120 days, sickle-shaped cells live only 10 to 20
  days.
• Sickle Cell Disease is most common among people
  from Africa, India, the Caribbean, the Middle
  East, and the Mediterranean.

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Citations

• http//www.news-medical.net/?id141
• http//learn.genetics.utah.edu/units/disorders/wha
  taregd/sicklecell/index.cfm