Normal Aminergic Synapse

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Normal Aminergic Synapse
www.pbs.org
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Aminergic Synapse Cocaine
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Downstream of Dopamine
Nestler Landsman, 2001
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Nestler, 2000
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Nestler, 2000
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Drosophila as a model system for the study of
drugs of abuse

• Conserved transmitter systems.
• Conserved behavioral responses to cocaine
  alcohol (Moore, 1998).
• Sensitization to repeated cocaine exposures.
• Genetics/reverse genetics.
• Genome project.

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Drosophila as a model system for the study of
drugs of abuse

• Reverse Genetics
• Show involvement of pathways similar to
  vertebrates loss of function/gain of function
• Forward Genetics
• Screen for new genes affecting cocaine behaviors

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Drosophila as a model system for the study of
drugs of abuse

• Results
• Expected Pathways
• Dopamine/Serotonin
• G protein signaling
• cAMP signaling pathways
• Unexpected Pathways
• Circadian pathways
• Tyramine a low abundance transmitter