Immune Escape Mechanisms in Leishmaniasis

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Immune Escape Mechanisms in Leishmaniasis

• Nancy Noben-Trauth, Ph.D.
• Assistant Professor
• Department of Microbiology, Immunology Tropical
  Medicine
• The George Washington University Medical Center
• nnoben_at_gwu.edu, 994-0531

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Visceral Leishmaniasis
Cutaneous Leishmaniasis
Self-healing ulcer
Leishmanization with live leishmania
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The Th1/Th2 Paradigm in Immunology
Leishmania
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The NEW Paradigm in Leishmania
IL-4R? KO mice are defective in Th2 responses,
but remain susceptible to Leishmania major
infection
IL-10
Th2
A New Immune Escape Mechanism
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Possible GWU Collaborations
IL-4R? KO mice to study Models of
Inflammation IL-10 gene analysis
Th2
Macrophages from IL-4R? KO mice produce IL-10