Human Papillomavirus HPV

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Human Papillomavirus (HPV)
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• 
  Wed, Nov 21 2007
• 
  Tanjung Jaya, Indonesia

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The Virus

• Papovaviridae
• infect skin and mucous membrane
• entry through clathrin mediated endocytosis to
  basal epithelia from micro-abrasions

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Epidemiology

• modes of transmission is skin to skin, mucous
  membrane contact
• perinatal transmission (rare) causing respiratory
  papillomatosis
• 45 women at age 20-24, anyone sexually active is
  at risk

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HPV types

• gt100 subtypes, 30-40 STD
• high-risk type HPV 16, 18, 35, 45 leads to
  cervical, vulva, vaginal cancer and other
  genitalia cancer including in men
• low-risk type HPV 6, 11 causes genital warts
• cutaneous HPV 1,2 skin warts

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• HPV type 16 and 18 cause nearly 70 of cases of
  cervical cancer
• HPV type 6 and 11 cause approx. 90 of genital
  warts
• Both 4 types cause 35-50 of all low grade
  cervical, vaginal and vulvar lesions

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Diagnosis

• abnormal PAP smear
• HPV DNA testing (problem- expensive, cannot
  distinguish active or latent)
• acetic acid-warts more visible

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Treatment and Prevention

• common skin and genital warts will regress
  spontaneously/ months/ years due to immune
  response
• common warts also can be eliminated using lasers
• vaccine Gardasil from Merck approved June 2006
  and Cervarix from GlaxoSmithKline approved May
  2007

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• trick body into thinking that there is HPV
  infection thus generates immune response
• vaccine does not cure HPV, it prevents thus not
  suitable for infected patient, but not 100
  prevention
• best prevention vaccine PAP smear annually
  (depends)

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HPV in Malaysia

• cervical cancer is 2nd most common cancer in
  women
• Gardasil has been approved during October 2006
• MSD collaborate with OGSM to spearhead Tell
  Someone campaign
• small figures for those who undergoes PAP smear
  each year

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Reference

• HPV
• http//alpha.montclair.edu/Williamss4/diagnosis.
  htm
• http//udel.edu/jlaverty/Human20Papilloma20Vir
  us.htmlPathogenesis__Symptoms
• http//en.wikipedia.org/wiki/Human_papilloma_viru
  sHPV_testing
• Cervical cancer is preventable 2007
  http//www.redorbit.com/news/health/884330/cervica
  l_cancer_is_preventable/index.html
• Tell Someone campaign in Malaysia
• http//www.msd-malaysia.com/content/corporate/ab
  out/news/2007/TellSomeone.html
• Indonesia Tree Man
• http//news.yahoo.com/s/nm/20071122/lf_nm_life/in
  donesia_tree_man_dc_1