Mechanism of action of hormones

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Hormone mechanism of action

• M.Prasad Naidu
• MSc Medical Biochemistry,
• Ph.D.Research Scholar

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Classification based on mechanism of action

• Group 1 bind to intracellular receptors.
• eg Androgens ,
• calcitriol,
• estrogens ,
• glucocorticoids
• progestrins
• thyroid hormones

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• Group II Bind to cell surface receptors .
• A. Second messenger cAMP
• ACTH, ADH, hCG, CRH,FSH, LH, PTH.
• B. cGMP as second messenger.
• ANF (atrial natriuretic factor)
• Nitric oxide (NO).

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• C. Calcium / phosphatidyl inositols as second
  messenger
• GnRH, TRH, PDGF, Substance P.
• D. Second messenger is a Kinase /phosphatase
  cascade
• Insulin, GH, prolactin , insulin like
  growth factors(IGF-1,IGF-2).

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