creativebiogene-antibodyandaptamerchoosewhichone-141130032812 (1)

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Antibody and Aptamer, Choose Which One?
Prepared by Creative Biogene
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Definition

• Aptamer is a term derived from the Latin aptus -
  fit, and the Greek meros  part. Aptamers
  are oligonucleic acid or peptide molecules that
  bind to a specific target molecule. By selecting
  from a large random sequence pool, we usually can
  get aptamers, but natural aptamers also are found
  in riboswitches. To narrow down, aptamers can be
  classified as
• DNA or RNA or XNA aptamers. They consist of
  (usually short) strands of oligonucleotides.
• Peptide aptamers. They consist of a short
  variable peptide domain, attached at both ends to
  a protein scaffold.

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Applications

• Aptamers can be used for both basic research and
  clinical purposes as macromolecular drugs.
  Aptamers can be combined with ribozymes to
  self-cleave in the presence of their target
  molecule. These compound molecules have
  additional research, industrial and clinical
  applications.

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Features

• Aptamers can bind to pre-selected targets,
  including proteins and peptides with high
  affinity and specificity and unlike actual
  genetic material, their specificity and
  characteristics are not directly determined by
  their primary sequence, but instead by their
  tertiary structure. And compared to antibodies,
  some aptamers exhibit stereoselectivity. Some
  aptamers (synthetic antibodies) have been
  generated that exhibit greater than 10,000-fold
  binding affinity for theophylline over caffeine,
  which differ from one another in structure by
  only a single methyl group.
• The picture shows a structure of aptamer

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• For sensors, therapeutic tools, cellular process
  regulation, as well as guiding drugs to their
  specific cellular targets, aptamers can help. 
• Aptamer Supplier
• Aptamer services provided by Creative Biogene
  include
• Aptamer synthesis
• Aptamer generation
• Cell SELEX
• Aptamer design and modification
• Other services negative selection (By means of
  negative selection techniques non-specific
  binders will be removed), aptamer-based
  precipitation, aptamer-based sensors and
  aptamer-based microarrays, allosteric/structure-sw
  itching aptamer.

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About Creative Biogene

• Creative Biogene is a US-based manufacturer and
  provider of genomics and proteomics products and
  services for academic and governmental research
  institutes, pharmaceutical and biotechnology
  industry.

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Contact to Inquiry

• USA45-1 Ramsey Road, Shirley, NY 11967, USATel
  1-631-626-9181Emailinfo_at_creative-biogene.comUni
  ted Kingdom St John's Innovation Centre, Cowley
  Road, Cambridge CB4 0WS, UK Tel
  44-207-048-3343 Emailinfo_at_creative-biogene.com
• Web http//www.creative-biogene.com/Services/Apta
  mers/Aptamers-Services.html