creativebiogene-genetherapytheapplicationofadenovirusvectors-141130033749-conversion-gate01

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Gene Therapythe Application of Adenovirus Vectors

• Prepared by
• Creative Biogene

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• In terms of genetic defect, abnormal genome is
  the bad source. If we could find the exact
  abnormal part and fix it, then the illness could
  be avoided, at least theoretically.
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• With thinking the same, many attempts have been
  made to treat the disorders by adding back the
  correct genetic information to individual cells.
  This is what we are going to talk todaygene
  therapy by adding foreign genetic material to
  treat disorders under this setting.

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• Dating back to 1970s the conceptual emerging,
  gene therapy trials used to treat human disorders
  actually really started after twenty years.
  However like every new thing stumbles, these
  initial trials did not add color to this exciting
  and promising field, might because of short of
  background and related knowledge. So the results
  at that time were initial dramatic clinical
  failures.

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• With the development of technology and constant
  accumulation of understanding, people begun to
  think about an alternateif we want the gene
  therapy to work, the correct genetic information
  has to be packaged and delivered to target cells,
  but how?

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The answer is adenovirus vectors. Adenoviral
packaging vectors are attractive options for its
unique features

• Low pathogenicity,
• High viral yields,
• Carry large genes, and
• Have transgene specific B and T cell responses

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• In addition to this, when packaged with
  recognizable antigens from various diseases,
  adenovirus vectors may serve as vaccines. Novel
  vaccines targeting complex pathogens like HIV,
  HCV, TB, malaria, influenza as well as cancer is
  a long-standing goal of human gene therapy.
• A team of scientists from Creative Biogene has
  developed exclusive techniques in adenovirus
  vector design and construction, as well as the
  generation of the adenovirus in high titer. With
  unique processes for the generation of new
  adenovirus constructs, Creative Biogene can
  provide the fastest turn-around time of any
  supplier in the industry.

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The services include

•   Clone gene of interest into appropriate
  transfer vector.  Transfect HEK 293 cells with
  recombinant viral DNA to produce recombinant
  adenoviruses.   Create high-titer recombinant
  adenovirus stock.

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Contact to order

• USA45-1 Ramsey Road, Shirley, NY 11967, USATel
  1-631-626-9181Emailinfo_at_creative-biogene.comUni
  ted Kingdom St John's Innovation Centre, Cowley
  Road, Cambridge CB4 0WS, UK Tel
  44-207-048-3343 Emailinfo_at_creative-biogene.com
• Web http//www.creative-biogene.com/Services/Cust
  om-Viral-Service/Adenovirus-service.html