NMR Services

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NMR Services by
Creative Biostructure
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NMR spectroscopy is a key analytical technique
for structure elucidation of a wide range of
materials from small molecules to compounds. The
technique provides detailed molecular information
that allows researchers have in-depth
understanding of composition, chemical structure,
morphology, and dynamics. NMR is particularly
useful in analysis of pharmaceuticals, screening
weak-binding compounds and developing into
drug-like inhibitors for drug discovery.
Supported by our NMR platform, Creative
Biostructure offers high quality customized
services ranging from production of
labeled-proteins to acquisition and analysis of
high-field NMR data for researchers in science
and pharmaceutical industry.
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Why Creative Biostructure? State-of-the-art
instruments Senior scientists with extensive
exerience Rapid turnaround time
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NMR services capabilities Compound structure
determination Chemical composition
analysis Molecular characterization Reaction
kinetics examination Quality control Dynamics,
disorder analysis Isotope-labeled protein
production Quantitative analysis Drug screening
and design NMR mapping for living cells
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Sample preparation guideline Labeling with
isotopes Protein NMR spectroscopy requires
isotope enrichment, such as 15N, 13C, 31P, 19F in
common. Samples with other isotope are also
acceptable. Size The molecular weight of
biomacromolecule of a NMR sample is typically
less than 50 KDa for high-resolution structure
elucidation. Larger proteins or complexes can be
studied to identify ligand/drug-binding site or
to characterize the physical state. Amount For
solution NMR, a sample typically contains 1-10
mg/ml or 0.3 mM purified protein in a suitable
buffer for solid-state NMR, we require larger
amount of samples, please talk to our specialist
for more information. Stability For most
in-depth studies by NMR, the protein needs to be
stable for several days at room temperature for
data acquisition.
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Contact Creative Biostructure Mailing Address
45-1 Ramsey Road Shirley, NY 11967, USA Email
Address contact_at_creative-biostructure.com Teleph
one Numbers 1-631 619 7922 Website
http//www.creative-biostructure.com/nmr-services_
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