Enzyme Target & Activator & Inhibitor Screening Service

1
Enzyme Target Activator Inhibitor Screening
Service
Profacgen
Free Powerpoint Templates
2
Profacgen offers a comprehensive list of
high-throughput screening services to
specifically and efficiently identify potential
enzyme substrates, activators and inhibitors.
3
Enzymes participate in numerous physiological
activities including signal transduction, cell
surface recognition and protein modification. To
determine possible targets of an enzyme,
Profacgen has developed a highly efficient
screening system to select candidate substrates,
inhibitors or activators by detection of
fluorescence, chemo-luminescence or isotopic
signal. Generally, the candidate molecules can be
selected or synthesized and then immobilized on a
solid surface. Detection is performed after
incubation with the target enzyme according to
the specific experimental design.
4
Profacgen provides enzyme target screening
service for kinase, phosphatase, protease,
methyltransferase, glycosyltransferase,
acetyltransferase and so on. You can profile your
target enzyme against thousands of substrate
compounds or proteins, or study various types of
protein modifications including phosphorylation,
methylation, ubiquitination, SUMOylation,
NEDDylation, and nitrosylation. Profacgen offers
thousands of substrates from sources including
human, rat, mouse, chicken and cow etc.
5
Profacgen also provides activator or enzyme
inhibitor screening service by adding candidate
compounds together with target enzyme into the
substrate. The effect of candidate compounds on
the kinetics of the given enzymatic reaction can
be quantified by the determination of EC50 or
IC50 compared to control groups.
6

• Our advantages
• Short turn-around time
• High efficiency
• Optimized experimental scheme
• Consistent results
• Customized service
• Combinatorial libraries available to fine-tune
  substrate sequence

7
Contact Profacgen Address 45-1 Ramsey Road
Shirley, NY 11967, USA Website
https//www.profacgen.com/