Appetite Controled by The Endocannabinoid System

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Appetite Controlled by The Endocannabinoid System
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What is Hunger?

• Hunger simply means a painful sensation or caused
  weakness by the desire for food or empty stomach.
  
• The primary hormones ghrelin and leptin have
  controlled the need for hunger. Ghrelin and
  laptin both are opposite of each other. Ghrelin
  increases your hunger when laptin decrease your hu
  nger.
• Because of ghrelin you feeling hungry which is
  produced in the stomach. Laptin is produced after
  consuming a meal in the fat cells.
• Hunger is very complex than this simple
  explanation. It is a very uncomfortable
  situation.

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How is Hunger mediated?

• Hormones and enzymes control the behavior and
  functions of our body. 
• The sensation of hunger is necessary because it
  makes us feel weather our body needs food intake
  or not.
• hunger is mediated by some mechanism which can
  be controlled by the endocannabinoid system. THC
  and CB1 are used to increase behavior related to
  intake of food.

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Positive Incentive Perspective

• Main positive augmentation of food is good taste
  by which we can feel hunger or motivate to eat.
• Endocannabinoid receives a rewarding signal, and
  they increase the firing rate of neurons.
• Endocannabinoid system regulates food intake in
  the central nervous system. This is the positive
  perspective theory of appetite.

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The Set-point Theory of Appetite

• When we consume food, Amino acid and
  carbohydrates are delivered into the blood and
  placed to cells.
• leptin is released when carbs and protein are
  felt. Blood sugar level and amino acid fall at a
  certain level that level can be called set point.
  After because of ghrelin we feel hungry again.
• Important primary hormones ghrelin and laptin
  has the important role in endocannabinoid system.
  Both have opposite effect in ECS, ghrelin
  encourages brain about how tasty food is and
  increase an appetite, and laptin decrease it.
  This both processes regulate our appetite and
  metabolism.

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