chimeric antigen receptors

1
CAR-T Therapy
2
Content
3
chimeric antigen receptors
4
chimeric antigen receptors
The typical structure of a CAR molecule includes
a single chain variable fragment (scFv), a
spacer, a transmembrane domain (TM) and an
intracellular signaling domain. The scFv is
derived from monoclonal antibody (mAb), which can
specifically recognize the target protein on
tumor surface and subsequently transduct
activation signal into CAR-T cell.
5
CAR publication
6
CAR publication
The original CAR-T or the first-generation CAR
consists of the intracellular domain from the CD3
?- chain and the primary transmitter of signals
from endogenous TCRs, which showed success in
pre-clinical trials and entered Phase I clinical
trials in ovarian cancer, neuroblastoma and
various types of leukemia and lymphoma. Here we
select some of the classical literature in the
field of chimeric antigen receptor technology. It
is hoped that these reviews and research articles
will help you to understand CAR technology
quickly and keep up with the cutting edge
development of this area.
??????
7
car t cell biomarker
8
car t cell biomarker
9
As a global company, we have more than 200
talented and well-trained scientists located in
different continents working closely with
partners from the entire world to develop and
produce medicines of tomorrow. Specifically, we
are the established leading expert in TCR and CAR
TNK cell immune therapy development, as we offer
the one-stop custom services that cover the
entire new drug development pipeline
10
Thanks