Paget’s Disease Of The Bone: Symptoms, Causes, Diagnosis and Treatment (1)

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Pagets Disease
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Pagets Disease

• Pagets disease of the bone is a long-term bone
  disorder resulting in the enlargement and
  deformation of bones. Pagets disease is the
  second most common type of bone disorder in the
  world. The excessive breakdown of tissue due to
  Pagets disease causes weak bones, fracture, and
  deformities. There are two types of Pagets
  disease of the bone Polyostotic (when multiple
  bone areas are affected) and Monostotic (when
  single area of bone is affected). Irregularities
  in the bone modelling process cause Pagets
  disease of bone. Pagets disease of the bone
  affects the normal skeletal structure of the
  body. 

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Causes of Pagets disease of the bone 

• The exact cause of Pagets disease is still
  unknown. Some of the believed causes of Pagets
  disease are 
• Genetic mutations
• Measles virus attacks
• Osteoclast cells malfunction
• Environmental factors
• Resorption of bone cells

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Symptoms

• The symptoms of Pagets disease depend on the
  area of the body part affected. However, symptoms
  of Pagets disease occur slowly over time and
  some patients may not feel any signs and symptoms
  of the disease. The most common symptom of
  Pagets disease is persistent pain in the joints.
  If Pagets disease is left untreated, it may
  contribute in the development of arthritis. The
  development of Pagets disease in the skull bone
  often results in severe headaches, nausea, vision
  problems, hearing loss, tingling and numbness
  around the face. The disease causes bones to
  transfer more than required calcium in the blood.
  The excessive amount of calcium in the blood
  results in extreme weakness, constipation, and
  loss of appetite. Another serious symptom of
  Pagets disease is change in the structure of
  bone. It can make your thighs, legs, and forehead
  look bigger than actual. 

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Pagets Disease
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Diagnosis of Pagets disease of the bone 

• Diagnostic tests for Pagets disease may
  include 
• CT (Computerized Tomography) - It is a technique
  in which several X-rays are taken from a
  different angle and combined later to make
  detailed images of the affected bones.
• MRI (Magnetic Resource Imaging) - It is an
  imaging test in which high frequency magnetic and
  radio waves are used to get detailed images of
  the affected bones.
• Bone scan - It involves the use of a small amount
  of radioactive solution, known as a tracer. This
  tracer is injected into the patients vein. A
  special camera is used to take pictures of areas
  that absorbed tracer.

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Treatments

• There is no permanent cure for Pagets disease
  its treatment can only help in the reduction of
  symptoms. Possible treatment of Pagets disease
  is 
• Medicines such as, acetaminophen and
  bisphosphonates provide relief from the pain,
  prevent bone loss, and control level of calcium
  in the body.
• Physical therapy, routinely exercise and
  certain vitamin D supplements prevent the Pagets
  disease from developing further.
• In particular cases an osteotomy procedure is
  performed. Osteotomy is a surgical procedure in
  which a segment of bone is removed to correct a
  misalignment.

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