The Clinical Application of CD19-CART Cells

1
The Clinical Application of CD19-CART Cells
2
The study of CD19 CART cells is currently a hot
spot for B-cell lymphomas. In 2010, Kochenderfer
et al. first reported the role of CD19-CART cells
in the treatment of relapsed and refractory
follicular lymphoma. In 2012, Kochenderfer et al.
reported that 8 patients with relapsed and
refractory B-cell lymphoma received CART cell
therapy, including 4 CLL, 3 follicular neoplasms,
and 1 splenic marginal B-cell lymphoma.
3
CD19-CART cells can recognize specific CD19
targets of B-cell lymphocytic leukemia. By
releasing cytokines such as perforin and
granzymes, CD19-CART cells attack the B
lymphocytes expressing CD19 antigen, thereby
prompting the body to eliminate malignant
lymphocytes. The US Sloan-Kettering Cancer Center
applied autologous 19-28z CART in the treatment
of refractory and relapsed B-ALL. Fourteen of the
16 patients had CR and were even effective in
relapsed Ph ALL after transplantation. Treatment
with CART also creates conditions for allogeneic
hematopoietic stem cell transplantation. The
University of Pennsylvania also reported the use
of 19-CD137zCART for the treatment of B-cell
tumors. Thirty patients with refractory and
relapsed B-ALL and 27 patients achieved CR. The
6-month disease-free survival rate was 67, and
the overall survival rate was 78.
4
Brenyjens et al. used second CAR T generation
cells, CD19-specific CART cells transfected with
CD28/CD3-?, to treat 5 patients with relapsed
B-ALL. The number and function of CART cells were
detected by PCR sequencing. The results showed
that CART cells could rapidly produce anti-tumor
effects in vivo, and the detection of minimal
residual disease turned to negative soon and
reached CR. Grupp et al. reported CR in 2
patients with refractory and relapsed B-ALL
treated with 2nd generation CART cells. One of
them was relapsed after umbilical cord blood
allogeneic hematopoietic stem cell
transplantation and had dual specificity for CD3
and CD19.
5
(No Transcript)
6
Contact us
45-1 Ramsey Road, Shirley, NY 11967, USA Email
marketing_at_creative-biolabs.com
7
Thank you