Cholestasis

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Cholestasis
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Cholestasis

• Cholestasis is a condition in which the normal
  flow of bile in the gallbladder is slowed or
  stopped resulting in itching and jaundices
  (yellowing of the skin, eyes, and mucous
  membranes).However, this condition can initiate
  in early pregnancy cholestasis is more common in
  the last trimester of pregnancy and generally
  goes away within a few days after
  delivery.Cholestasis occurs in about one woman
  out of 1,000 overall, and in multiple
  pregnancies. It has a high risk of recurrence in
  future pregnancies. This disease is also referred
  to as intrahepatic (in the liver) cholestasis of
  pregnancy and pruritus gravidarum (severe
  itching).

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What causes cholestasis?

• The gallbladder is an organ attached to the
  lower part of the liver. It serves as a holding
  reservoir for bile that is produced in the liver.
  Bile acids are important in the breakdown of fats
  in digestion. Byproducts in the blood are
  converted to a part of bile called bilirubin.It
  is thought that hormones in pregnancy affect
  gallbladder function, resulting in slowing or
  stopping of the flow of bile. This causes a
  buildup of bile acids in the liver, which can
  spill into the bloodstream causing itching.
  Jaundice may also result when bilirubin levels
  build up.

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How is cholestasis diagnosed?

• In addition to a complete medical history and
  physical examination, generalized severe itching
  without a rash is often the first clue to
  diagnosis. Blood tests for liver function, bile
  acids, and bilirubin often show changes which may
  also aid in the diagnosis.

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What are the symptoms of cholestasis?

• The following are the most common symptoms of
  cholestasis. However, each woman may experience
  symptoms differently. Symptoms may include
• Overall itching, especially the palms of the
  hands and soles of the feet
• Benign nausea and discomfort in the upper right
  abdomen
• Dark urine color
• Light coloring of stools (bowel movements)
• Jaundice (yellow coloring of skin, eyes, and
  mucous membranes)
• The symptoms of cholestasis can resemble with
  other medical conditions. Always consult your
  doctor for a diagnosis.

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Treatment for cholestasis

• The treatment for cholestasis will be determined
  by your doctor depending upon
• Pregnancy, overall health, and medical history
• Extent of the disease
• Tolerance for specific medications, procedures,
  or therapies
• Expectations for the course of the disease
• Your opinion or preference
• The main aim of treating cholestasis is to lower
  down the itching and prevent complications.
  Itching can be easily treated with topical
  anti-itch medications or with corticosteroids.At
  times, medicines are also used to help and
  decrease the concentration of bile acids. Fetal
  monitoring tests may be used to check the
  well-being of the fetus.Babies of women with
  cholestasis are often delivered early (usually
  around 37 weeks) because of the risk to the
  fetus.

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