Chronic Inflammatory Demyelinating Polyneuropathy

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Chronic Inflammatory Demyelinating
Polyneuropathy
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Chronic Inflammatory Demyelinating
Polyneuropathy

• Chronic inflammatory demyelinating
  polyneuropathy (CIDP) is a neurological disorder
  that is characterized by gradually increasing
  sensory loss and weakness associated with the
  loss of deep tendon reflex in the legs and
  arms.Chronic inflammatory demyelinating
  polyneuropathy (CIDP) is a progressive motor and
  sensory neuropathy which is very painful and
  debilitating.The axon (nerve fiber) works like
  an electric wire. The myelin sheath around the
  axon is the insulation that is necessary for the
  nerve to conduct electrical impulses
  properly.In chronic inflammatory demyelinating
  polyneuropathy (CIDP), myelin is attacked through
  very complex mechanisms. In such cases, the body
  sees the peripheral nerve as foreign and
  antibodies bind to the myelin and initiate to
  break it down.For example, if you are willing
  to move your finger, messages tell your brain to
  move the finger. Then electrical communication
  inside your body tells your nerves and muscles to
  move the finger. When there is disruption in the
  myelin sheath, those messages are weakened.

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Symptoms

• Your brain is telling your finger to move but
  the nerves are damaged and the movement is
  weakened, delayed, or absent. When the myelin
  sheath is completely ruptured, the message is
  blocked and this is called paralysis.However, a
  neurologist that has experience in this type of
  disease should be able to identify the gradual
  symptoms and rule out any other cause. Typically,
  a diagnosis of chronic inflammatory demyelinating
  polyneuropathy (CIDP) is based on the persons
  symptoms. Common symptoms in chronic inflammatory
  demyelinating polyneuropathy (CIDP) patients
  include
• In extremities

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Symptoms
Continue

• Pain
• Tingling
• Numbness
• Weakness
• Loss of deep tendon reflex
• Foot drop
• Difficulty walking (altered gait, stumbling)
• FatigueIn addition to the symptoms, tests like a
  nerve conduction study (NCS) and electromyography
  (EMG) a diagnostic procedure to assess the
  health of muscles and the nerve cells that
  control them can be administered to determine the
  extent of demyelinating disease. In this
  disease, there is a damage done to the lining of
  the nerves that are important for electrical
  nerve conduction. This can be confirmed by EMG
  studies or nerve biopsy. A nerve biopsy is done
  to affirm the inflammatory process in patients
  nerve.

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Diagnosis

• A spinal fluid analysis is another diagnostic
  test that helps determine if a patient has
  elevated protein with normal cell count, an
  abnormality found in chronic inflammatory
  demyelinating polyneuropathy (CIDP) patients.At
  the end, your doctor may perform blood and urine
  tests to extract other diseases that may cause
  neuropathy, like diabetes, which is the number
  cause of peripheral neuropathy.The therapy for
  chronic inflammatory demyelinating polyneuropathy
  (CIDP) includes these three primary protocols

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Diagnosis
Continue

• IVIG (intravenous immunoglobulin is used to treat
  many autoimmune, infectious, and idiopathic
  diseases) can aggravate kidney dysfunction,
  cardiovascular disease, cerebrovascular disease,
  and other.
• Corticosteroids (oral prednisone, pulse oral
  dexamethasone, IV methylprednisolone) often
  improve strength, are conveniently taken by
  mouth, and are inexpensive. Side effects,
  however, can limit long-term use.
• Plasma exchange It is a process through which
  some of the patients blood is extracted and the
  blood cells returned without the liquid plasma
  portion of the patients blood. It may work by
  removing harmful antibodies present in the
  plasma. Short-term relief.

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Treatment

• If treated early, most chronic inflammatory
  demyelinating polyneuropathy (CIDP) people
  respond well to therapy that can reduce the
  damage to peripheral nerves and contribute to
  improved function and quality of life.If left
  untreated, 30 of chronic inflammatory
  demyelinating polyneuropathy (CIDP) patients will
  progress to wheelchair dependence.

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