Bispecific t cell receptor

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Bispecific T Cell Receptor
www.creative-biolabs.com/car-t
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Bispecific TCR is a molecule that can regulate
the bodys immune system by redirecting and
promote the T-cell response towards cancer cells
with specific tumor targets.
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Background
The TCR is a molecule existed on the surface of T
cells, or T lymphocytes. Its responsibility is to
recognize fragments of antigen to provide
peptides bound to major histocompatibility
complex (MHC) molecules. The relationship between
the binding TCR and antigen peptides is
unrestricted and gradually degenerated, which
means that TCRs and antigen peptide are not in a
biunique relationship. Typically, the TCR is made
up of two different protein chains. After being
combined with antigenic peptide and MHC
(peptide/MHC complex) via TCR, the T lymphocyte
will be activated through signal transduction.
This is a series of biochemical events mediated
by associated enzymes, co-receptors, and
specialized adaptor molecules, resulting in
activation of transcription factors.
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Introduction of Bispecific TCR
Bispecific TCR molecules can leverage the bodys
immune system by regulating the T-cell response
towards cancer cells with specific tumor targets.
There are two domains of our bispecific T-cell
receptor. One of them is an affinity-maturated
and highly selective TCR domain that can
recognize and bind to a tumor-specific peptide
target presented in the context of HLA class I
receptor, the other is a T-cell recruiting
antibody domain directed against CD3 or other
immuno-modulating T-cell surface proteins. The
characteristic of these novel receptors allows T
cells to be activated and attack the tumor,
regardless of the T cells intrinsic specificity.
After being administrated to the patients, our
bispecific TCR will selectively bind to the
surface of targeted tumor cells. Then the
bispecific TCR will recruit and activate T
cells via CD3 binding initiates tumor killing.
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Fig 1. Antigen presentation stimulates T cells
with the help of TCR.
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Features
Ph.D. level scientists and skillful technicians
Extensive experience
Capable of affinity optimization
Low off-target toxicity
Superior quality
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About

• With the exponentially increased demand in modern
  novel medicine, the CAR and TCR immune cell
  therapy has been one of the most promising
  approaches for target-specific cancer treatment.
  With integrated global resources in all aspects,
  Creative Biolabs provides one-stop full CAR T/NK
  Cell therapy development service, including early
  non-clinical research, process development,
  pre-clinical animal model testing, cGMP
  manufacturing, and phase I-III clinical trials.

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Contact

• 45-1 Ramsey Road, Shirley, NY 11967, USA
• Email marketing_at_creative-biolabs.com
• www.creative-biolabs.com/car-t

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Thank You