antibody drug conjugate

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Antibody Drug Conjugate
https//www.creative-biolabs.com/adc/
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Monoclonal antibody-based immunotherapies against
cancer and other infectious diseases are highly
advantageous comparing to conventional
therapeutic approaches due to their high
specificity and affinity towards well-defined
targets. Antibody-drug conjugates (ADCs) inherit
such superiorities and more remarkably, expand
the therapeutic window of the conjugated drugs
(payloads), which are usually highly toxic and
diverse in their biochemical nature.
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ADC mode of action.
ADC molecules travel to the tumor site via
systematic circulation, bind to tumor surface
antigens, and enter the tumor cells via receptor
mediated endocytosis (internalization). The
payload is released in the cytosol or lysosome to
eliminate the cancer cell by disrupting important
cellular pathways (microtubule assembly, DNA
transcription, mRNA processing).
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ADC molecules travel to the tumor site via
systematic circulation, bind to tumor surface
antigens, and enter the tumor cells via receptor
mediated endocytosis (internalization). The
payload is released in the cytosol or lysosome to
eliminate the cancer cell by disrupting important
cellular pathways (microtubule assembly, DNA
transcription, mRNA processing).
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Three major components define an ADCthe
monoclonal antibody, a cytotoxic payload, and a
molecular linker that covalently bridges the
other two components. A successful ADC should be
chemically and physiologically stable in blood
stream, exert similar antigen binding pattern
compared with the unconjugated antibody, and
exhibit desired payload toxicological effects
once internalized.
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Designing of an ADC is an elaborate process that
involves careful planning, meticulous execution,
and intensive trouble-shooting. An effective
combination of the most suitable components will
greatly increase the chance for a successful ADC.
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About

• After years of pursuit for perfection, Creative
  Biolabs has established our leadership in
  targeted immunotherapy and antibody-drug
  conjugate (ADC) development. Creative Biolabs
  offers customers with comprehensive one-stop-shop
  of all aspects in ADC research and evaluation,
  ranging from antigen selection, antibody
  production/optimization, payload-linker
  synthesis, ADC conjugation, to various stages of
  ADC characterization and pre-clinical evaluation.
  Furthermore, inventory also contains an extensive
  list of linkers, payloads, payload-linker sets,
  and commonly used ADCs for quick deployment and
  concept validation.

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Contact

• 45-1 Ramsey Road, Shirley, NY 11967, USA
• Email marketing_at_creative-biolabs.com
• www.creative-biolabs.com/car-t

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