car t target

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Biomarker Identification Selection

• Referenceshttps//www.creative-biolabs.com/car-t/
  biomarker-identification-selection.htm

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What is cancer biomarker?

• In a broad sense, it's an indicative of the
  presence of cancer in the body or a molecule
  secreted by a tumor or a specific response of the
  body to the presence of cancer. It is usually
  identifiable or measurable in the blood, urine or
  other convenient body fluids by PCR, ELISA, and
  other conventional immune assays.
• can be categorized into genetic, epigenetic,
  proteomic, glycomic, and imaging biomarkers for
  cancer diagnosis, prognosis, and epidemiology.

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What is cancer biomarker?

• In a narrow sense of cancer biomarker, it is
  limited to proteins the most used to challenge in
  the clinical applications, especially in the
  CAR-T therapy. Specifically, a cancer biomarker
  of the CAR-T provides the most prominent signal
  of cancer cells for distinguishing from normal
  cells and the most effective CAR T target for
  immune recognition and destruction.

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Characteristics

• Involve in the canceration process, correlate
  with the disease changes, like deterioration and
  improvement
• Manifest as a relatively high expression or even
  unique expression on the surface of cancerous and
  precancerous tissue than other normal cells to be
  measured and distinguished easily and reliably
  for an acceptable safety, especially the mutant
  proteins, which is the most specific biomarkers
  for the only origination from an existing tumor
• Relatively stable in response to other unrelated
  factors.

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• Like AFP for liver cancer, BCR-ABL for chronic
  myeloid leukemia, BRCA1/BRCA2 for breast/ovarian
  cancer, BRAF V600E for melanoma/colorectal
  cancer, CA-125 for ovarian cancer, CA19.9 for
  pancreatic cancer, CEA for colorectal cancer,
  EGFR for non-small-cell lung carcinoma, HER-2 for
  breast cancer, KIT for gastrointestinal stromal
  tumor, PSA for prostate cancer, S100 for
  melanoma, etc.

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Biomarker identification selection
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Biomarker identification selection

• Recommend the most applicable target according to
  specific type of cancer and customs requirements,
  or design subsequent and further technique
  service based on designated target
• Screen originally for novel potential target
  based on customized conditions, which is an
  advanced optional service with relatively higher
  technique requirement and price.

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