Glycogen metabolism

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Glycogen Metabolism
R. C. Gupta Professor and Head Department of
Biochemistry National Institute of Medical
Sciences Jaipur, India
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EMB-RCG
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EMB-RCG
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Glycogen is synthesized from glucose
Synthesis of glycogen is known as glycogenesis
Glycogen is broken down to glucose
Breakdown of glycogen is known as glycogenolysis
EMB-RCG
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Glycogenesis
EMB-RCG
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Regulation
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E M B - R C G
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EMB-RCG
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Intracellular concentration of cAMP is regulated
by some hormones
So, the ultimate regulators of glycogenesis are
epinephrine, glucagon and insulin
Epinephrine and glucagon increase the
concentration of cAMP
Insulin decreases the concentration of cAMP
EMB-RCG
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Glycogenolysis
E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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(Glucose)n Pi
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E M B - R C G
Phosphorylase
(Glucose)n?1 Glucose-1-phosphate
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Regulation
E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Thank you