Metabolism of amino acids - PowerPoint PPT Presentation

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Metabolism of amino acids

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Digestion of proteins, absorption of amino acids, synthesis of amino acids, catabolism of amino acids and disposal of urea – PowerPoint PPT presentation

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Title: Metabolism of amino acids


1
Metabolism of Amino Acids
R. C. Gupta Professor and Head Department of
Biochemistry National Institute of Medical
Sciences Jaipur, India
2
E M B - R C G
EMB-RCG
3
E M B - R C G
EMB-RCG
4
E M B - R C G
EMB-RCG
5
E M B - R C G
EMB-RCG
6
E M B - R C G
EMB-RCG
7
E M B - R C G
EMB-RCG
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Nitrogen balance
E M B - R C G
10
E M B - R C G
11
E M B - R C G
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Nitrogen equilibrium
E M B - R C G
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Positive nitrogen balance
E M B - R C G
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Negative nitrogen balance
E M B - R C G
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Essential and non-essential amino acids
E M B - R C G
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E M B - R C G
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E M B - R C G
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Digestion and absorption
E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
EMB-RCG
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EMB-RCG
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E M B - R C G
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E M B - R C G
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Pancreatic juice
EMB-RCG
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EMB-RCG
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E M B - R C G
EMB-RCG
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E M B - R C G
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E M B - R C G
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E M B - R C G
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EMB-RCG
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Synthesis of non- and semi-essential amino
acids
E M B - R C G
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Alanine
E M B - R C G
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Aspartate
E M B - R C G
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Serine
E M B - R C G
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Glutamate
E M B - R C G
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Glutamine
E M B - R C G
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Cysteine
E M B - R C G
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E M B - R C G
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Tyrosine
E M B - R C G
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E M B - R C G
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E M B - R C G
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Proline
E M B - R C G
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Hydroxyproline
E M B - R C G
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E M B - R C G
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E M B - R C G
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Hydroxylysine
E M B - R C G
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Arginine
E M B - R C G
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Histidine
E M B - R C G
82
Protein turnover
E M B - R C G
83
E M B - R C G
84
EMB-RCG
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Lysosomal degradation
E M B - R C G
EMB-RCG
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E M B - R C G

87
E M B - R C G
EMB-RCG
88

Cytosolic degradation

EMB-RCG
89
E M B - R C G
EMB-RCG
90

E M B - R C G
EMB-RCG
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E M B - R C G
EMB-RCG
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E M B - R C G
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E M B - R C G
95
Half-lives of proteins
E M B - R C G
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EMB-RCG
97
E M B - R C G
EMB-RCG
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E M B - R C G
99
Catabolism of amino acids
E M B - R C G
100
E M B - R C G
101
E M B - R C G
102

Fate of carbon skeletons
EMB-RCG
103
E M B - R C G
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E M B - R C G
106
E M B - R C G
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Amino acids forming pyruvate
E M B - R C G
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Hydroxyproline
E M B - R C G
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E M B - R C G
116
Amino acids forming a-ketoglutarate
E M B - R C G
117
E M B - R C G
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E M B - R C G
120
E M B - R C G
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E M B - R C G
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E M B - R C G
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Amino acids forming succinyl coenzyme A
E M B - R C G
127
E M B - R C G
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E M B - R C G
130
E M B - R C G
131
E M B - R C G
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E M B - R C G
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Amino acids forming fumarate
E M B - R C G
138
Amino acid forming oxaloacetate
E M B - R C G
139
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141
Amino acids forming acetyl coenzyme A
E M B - R C G
142
Phenylalanine and tyrosine
E M B - R C G
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Tryptophan
E M B - R C G
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E M B - R C G
150
E M B - R C G
151
Lysine
E M B - R C G
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155
E M B - R C G
156
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158
Synthesis of non-protein specialized products
Hormones
Pigments
E M B - R C G
Specialized products synthesized from amino
acids
Porphyrins
Purines
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160
Glycine
E M B - R C G
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162
E M B - R C G
163
E M B - R C G
164
E M B - R C G
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E M B - R C G
168
E M B - R C G
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Methionine
E M B - R C G
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Cysteine
E M B - R C G
173
E M B - R C G
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E M B - R C G
176
Arginine
E M B - R C G
177
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178
Histidine
E M B - R C G
179
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180
Tyrosine
E M B - R C G
181
E M B - R C G
182
E M B - R C G
183
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184
E M B - R C G
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E M B - R C G
187
E M B - R C G
188
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189
Melanin, the black pigment present in skin, hair
and iris, is formed from tyrosine
The exact structure of melanin is not known
E M B - R C G
These two are formed from tyrosine
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191
Tryptophan
E M B - R C G
192
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194
E M B - R C G
195
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196
Thank you
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