Host cell protein

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host cell protein analysis

• Host Cell Proteins (HCPs) are a heterogeneous,
  complex group of proteins that derived from the
  host cell. HCPs differ significantly in molecular
  mass, isoelectric point, hydrophobic properties,
  and structures. Figure 1 shows a harvested
  product pool of bacterial and mammalian
  fermentation by two-dimensional difference gel
  electrophoresis (2D-DIGE). Identification and
  quantification HCPs is very important in the
  development of biopharmaceutical products to
  ensure product purity and patient safety.
  Protease of HCPs can influence the protein
  pattern in culture and influence the purification
  process. In addition, HCPs can undergo
  post-translational modifications that make
  quantification and characterization more
  difficult. Moreover, high HCP variance results
  in different biochemical properties which could
  cause an immune response or allergic reactions
  even anaphylactic shock.

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Contact

• Provider Creative Proteomics
• URL http//www.creative-proteomics.com/services/h
  ost-cell-protein-analysis.htm
• Email contact_at_creative-proteomics.com
• Phone No. 1-631-619-7922