FET might be susceptible to an imperfect environment

1
FET might be susceptible to an imperfect
environment

• Mohak Laparoscopy and Infertility Center

2

FET might be susceptible to an imperfect
environment
3
Can FET and fresh ET outcome in IVF cycles be
affected by the open environment air pollution?
INTRODUCTION IVF outcomes and human
infertility can be a result of air pollution
around us. Its indicated in Choe et al 1 study
that lower pregnancy rates in IVF cycles can be
associated with ambient air pollution while
controlled ovarian stimulation as well as the
post-transfer period. Choe et al1 study indicated
lower pregnancy rates in IVF cycles may be linked
to ambient air pollution during controlled
ovarian stimulation and the post-transfer period.
Do the outcomes of frozen-thawed embryo transfer
(FET) and fresh transfer are differentially
affected by open-air pollution?
4
SUMMARYBetween January 2013 and December 2016,
Wang et al 2 studied the adverse effects of air
pollution in 11148 patients contributing to 16290
transfer cycles for IVF treatment cycles. The
average age of the cohort was recorded to be 31.5
years. In order to estimate the daily ambient
exposures to six main pollutants ( CO, O 3 , SO 2
, NO 2 , PM 2.5 , PM 10 ) inverse distance
weighing interpolation was used at an IVF
clinical site, bestow to the data recorded at the
fixed air quality monitoring stations inside the
city. The exposure for every cycle was shown as
the daily mean concentration of contaminants
(pollutants) from oocyte retrieval to embryo
transfer/cryopreservation. Analysis of exposures
was performed on every quarter basis. A general
equating estimate was used to study the
relationship between pollutants and IVF results.
The rate of clinical pregnancy and the rate of
live birth of the course were recorded to be
55.1 and 47.1 respectively. 4013 patients among
the included cycles, got 5299 FET cycles,
bringing about 42.7 live birth per ET, while
9553 patients got 10991 new transfer cycles,
bringing about 49.2 to live birth per ET. Raised
SO 2 and O 3 levels were essentially related with
lower rates of live birth in FET cycles, while
none of the pollutants was significantly linked
with bringing down of IVF results in new transfer
cycles. The FET cycles in the most elevated
quartile of SO 2 and O 3 exposure had essentially
lower rates of live birth (balanced OR) in
correlation with those in the least quartile.
Models including all transfer cycles and
collaboration terms (FET exposures) recommended
that FET altogether improved the impacts of SO 2
and O 3 exposures on IVF results (P lt 0.001).
Representing every six contaminations, women in
the top quartile of SO 2 still had the least
rates of live birth (OR 0.61, 95CI 0.470.80).
5
CONCLUSION According to this study, embryos may
be more vulnerable to a suboptimal environment
which are undergoing FET in comparison to those
which are undergoing fresh transfer. Elevated SO
2 and O 3 levels at the location of IVF were
found to be significantly linked with lower rates
of live birth following FET whereas it did not
show any adverse effect on the contemporary new
transfer results. In the locations and seasons
which are heavily polluted, due to dynamic
changes of the ambient air pollutant
(specifically gaseous), fluctuation in FET
outcomes can be seen.
REFERENCES 1. Xin Li Wang, Jiali Cai, Lanlan
Liu, Xiaoming Jiang, Ping Li, Aiguo Sha, Jianzhi
Ren Association between outdoor air pollution
during in vitro culture and the outcomes of
frozen-thawed embryo transfer, Human
Reproduction, Volume 34, Issue 3, 1 March 2019,
Pages 441451, https//doi.org/10.1093/humrep/dey3
86  2. Choe SA, Jun YB, Lee WS, Yoon TK, Kim
SY. Association between ambient air pollution and
pregnancy rate in women who underwent IVF. Hum
Reprod. 2018 Jun 133(6)1071-1078. doi
10.1093/humrep/dey076. PubMed PMID 29659826
6
Mohak laparoscopy and infertility center, part
of a multispecialty advanced care facility, is
the best infertility hospital in Indore. Mohak
IVF is the best fertility center in Indore, India
with advanced technology, interactive caring
hospitality and great success rate. The
affordable IVF treatment cost makes it
preferential for the couples in need of
infertility treatment, Test-tube Baby treatment,
and IVF treatment. The IVF specialist, doctors
and the professional staff of center offers IVF,
andrology, embryology, assisted reproductive
technology, ICSI treatment and also offers IVF
financing at our fertility center. To book an
appointment with the Doctors/ best IVF specialist
at the best IVF center in MP, Indore, Call-
78980-47572 / 80852-77666
Mohak IVF- test tube baby center is one of the
Best infertility hospital in indore provides
infertility treatment with high international
standards and assisted reproductive technologies
like IUI, IVF/ICSI treatment, IMSI etc. Mohak IVF
provides high success ratio IVF treatment at
affordable ivf cost in indore . Highly
experienced and fully professionals ivf
specialist/doctor in indore give their full
efforts to make your parenthood dreams comes true.
7
(No Transcript)