Breast cancer treatment by Everolimus Therapy

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Breast Cancer Treatment by Everolimus Therapy
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What is Everolimus? Everolimus is a targeted
therapy which blocks the spread and growth of
cancer cells. Everolimus is the generic name
for the medication Afinitor, which is
manufactured by Novartis.
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Everolimus / Afinitor use This medication is
used for the treatment of HER2-negative or
advanced hormone receptor positive breast cancer
in Post-menopausal women. Currently this
medication is used for the treatment of renal
cell cancer, other tumours. This medication can
also be used to prevent rejection of organ
transplants as an immunosuppressant.
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Everolimus Mechanism of Action Everolimus is a
mammalian target of rapamycin (mTOR) inhibitor.
And this mTOR is a type of protein which is known
to be kinase. Kinase main work is to fulfil
energy requirement of cells in our body, be it
healthy cells or cancer cells. And when these
kinases dont work properly, they help in the
growth of cancer cells in breast. The mTOR
inhibitors like Everolimus works by interfering
with kinase and stopping the cancer cells to get
their energy requirements fulfilled.
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Afinitor Cost How Everolimus tablets
given? Everolimus tablets are generally taken
one tablet a day, with or without food, alongside
with the hormone therapy medication exemestane.
Its recommended to follow your prescribed
physicians instructions for taking this
medicine. Also avoid taking grapefruit or
grapefruit juice while taking this medicine, as
this may act as a hindrance in the working of the
medicine.
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• Common side effects
• Risk of Infection
• Skin changes
• Sore mouth and taste change
• Fatigue
• Constipation or Diarrhoea
• Shortness of breath and coughing
• Raised blood glucose levels.
• Bruising and bleeding
• Anaemia
• Nausea and vomiting
• High cholesterol

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Rare side effects Heart changes weakening
of heart muscles, chest pain or changes in your
heartbeat. Slow wound healing   If you are
concerned about any of the above side effects or
side effects which are not listed above, talk to
physician as soon as possible.
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Everolimus Cost Contact your Physician/Hospital
immediately if Body temperature rises over
37.5C or temperature falls under 36C, or
whatever your physician has advised Suddenly you
feel unwell, even with a normal temperature you
have any symptoms of an infection, for example a
cough throat, feeling shivery or cold, a sore
throat, and need to pass urine frequently.
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Some Clinical trials proving Everolimus
efficacy. Breast Cancer Trial of Oral
Everolimus-2 Clinical Trials Everolimus along
with exemestane was approved for treating HER2
negative and HR-positive metastatic breast cancer
after anastrozole or letrozole treatment had not
shown successful.  The results of this study
showed that progression free survival was 4
months more for everolimus exemestane
treatment. The median PFS for exemestane
placebo group was 2.8 months as compares to
everolimus exemestanes 6.9 months.
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TAMRAD trial The TAM-RAD trial examined the
everolimus tamoxifen combination versus
tamoxifen alone. A total of 111 patients were
enrolled in this study. Out of which 57 were
selected at random and were given tamoxifen alone
and 54 were given everolimus tamoxifen. The
results depicted that the clinical benefit rate
(stable disease of gt 6 months in study duration)
was 42.1 in tamoxifen group as compared to 61.1
in everolimus tamoxifen group. Also, the PFS
for everolimus tamoxifen was found to be 8.6
months as compared to 4.5 months in Tamoxifen
group.
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BRE-43 study In this study everolimus was
combined with fulvestrant for treating metastatic
breast cancer and the results were analysed.
Out of 31 patients analysed, median time for
PFS was 7.4 months and the median Overall
survival was 24 months. However, a total of 33
of the patients enrolled exhibited de novo
resistance to the treatment.
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Triple-negative Tumours Triple-negative tumour
are generally at an advanced stage of the breast
cancer at the time of diagnosis. During the
phase 2 of trial, everolimus was combined with
carboplatin, which demonstrated efficacy of this
combination. The clinical benefit rate was 36
and median PFS was 3 months.
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The information provided on the page is meant
for the purpose of being helpful and educational.
It should not be considered as medical
advice.   Afinitor, everolimus, afinitor cost,
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