Gastric Cancer Treatment with Docetaxel

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Gastric Cancer Treatment with Docetaxel
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What is Docetaxel? Docetaxel brand name Taxotere
is an anti-cancer chemotherapy medication which
is classified as an antimicrotubule agent. This
medication has been in the market since 2004, and
has shown tremendous results among patients.
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Docetaxel Mechanism of action Chemotherapy drugs
kills the cancer cells depends upon their ability
on how fast they halt the division of cells.
Docetaxel medications main function is to
damage the DNA or RNA cells which copy itself in
the division. With this drug working, cancer
cells are not able to divide, thus leading to
death of these cells.
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Antimicrotubule agents like Docetaxel (Brand
Taxotere) inhibits the microtubule structures
within cells. These microtubules plays a major
role in replicating and dividing of cells, and
docetaxel results in the untimely death of these
cells.
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• Docetaxel Cost information
• Docetaxel side effects
• Common side effects
• Numbness, Burning, pain, or tingling in the arms,
  hands, legs, or feet
• Stomach, fingers, face, hands, feet, or lower
  legs gets swelled
• weakness or tiredness
• gain of weight

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• Less Common side effects
• Black, tarry stools
• blood in the stool or urine
• hoarseness or cough
• difficulty in breathing
• difficult or painful urination
• difficulty in swallowing
• dizziness

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• Fast Heartbeat
• Chills Or Fever
• Skin Rash Or Hives
• Itching, Swelling Or Puffiness Of The Eyelids
• Pain In Side Or Lower Back
• Rattling And Noisy Breathing
• Clear Red Spots On The Skin
• Severe Red, Scaly, Peeling, Or Swollen Areas Of
  The Skin
• Feeling Tightness In Chest
• While Resting Feeling Trouble In Breathing
• Unusual Bruising Or Bleeding

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• Rare side effects
• Pain Or Discomfort In Chest
• Blood Pressure Gets Decreased
• Irregular Or Unusually Fast Heartbeat
• Blood Pressure Gets Increased

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And If any of the above symptoms reaches a
unacceptable or beyond your limits, contact you
doctor immediately.   Docetaxel Dose for
treatment of Gastric Cancer in Adults On day 1,
75mg/m2 intravenous dose of docetaxel over 1 hour
which is followed by cisplatin 75mg/m2 over 1 3
hours which is further followed by 5-fluorocil
750mg/m2 as 24 hours continuous infusion.
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This should be followed for days 1 to 5,
beginning with the end of cisplatins infusion.
And this process is continued for 3 weeks,
until there is unacceptable toxicity in the body
or the disease progression.
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Proving Docetaxels efficacy in Gastric Cancer As
per FLOT 4 trials phase 3, perioperative
chemotherapy with docetaxel can be considered the
new standard care for gastroesophageal junction
adenocarcinoma. According to the results of
phase 2 trial of FLOT 4, it was observed that
combination of docetaxel, oxaliplatin, and
fluorouracil/leucovorin was tolerable and has
been encouraging rates of pathological response
in GEJ adenocarcinoma and gastric cancer patients.
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The results were obtained by randomising 716
patients (having a median age of 62 years) to
combination of docetaxel, oxaliplatin, and
fluorouracil/leucovorin (FLOT) or epirubicin,
cisplatin, and capecitabine (ECF/ECX)
combination. 356 patients were given the former
combination and remaining 360 patients were given
the latter combination. Docetaxel Price
information
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Between both ECF/ECX and FLOT, baseline
characteristics seemed to be similar. After a
follow of almost 3.5 years, it was found out that
203 patients in ECX/ECF group have died as
compared to 166 in FLOT group. The median
Overall Survival was 35 months in ECF/ECX group
as compared to 50 months in FLOT group. FLOT
group also showed improvement in Progression free
survival with a median of 30 months as compared
to 18 months in ECF/ECX group.
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According to the sensitivity analyses, it was
observed that FLOT group showed increased rate of
curative surgery and prolonged Overall survival
and progression free survival as compare to
ECF/ECX group. Both the groups experienced
perioperative complications in half patients of
their respective groups. The 30-day mortality
rate was 3 in ECF/ECX group as compared to 2 in
FLOT group and 90-day mortality rate was 8 in
ECF/ECX group as compared to 5 in FLOT group.
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It was also observed that ECF/ECX group suffered
more of grade 3/4 vomiting and nausea and FLOT
group suffered more of grade 3/4
neutropenia. The information provided on the
page is meant for the purpose of being helpful
and educational. It should not be considered as
medical advice.   Docetaxel, docetaxel side
effects, docetaxel dose, docetaxel mechanism of
action, docetaxel brand name, what is docetaxel,
docetaxel price, docetaxel cost
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