Pomacel 2mg capsule - Pomalidomide | Myapplepharma

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Pomacel 2mg capsule - Pomalidomide Myapplepharma
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• Pomacel 2mg is a Glenmark Pharmaceuticals product
  which is endorsed by FDA, containing an active
  anti-cancer drug called Pomalidomide. 
• Pomacel 2mg is available as orally bioavailable
  thalidomide derivative with various therapeutic
  activities such asImmuno modulatoryAnti-angioge
  nesisAnti-neoplastic 
• Pomacel 2mg is like thalidomide Lenalidomide
  with related to decreased rate of serum
  aminotransferase elevations during treatment.
  This may lead to severe liver injury.Pomacel
  2mg is involved in the treatment for regression
  unmanageable multiple myeloma.Pomacel 2mg is
  used in the patients who are failing to response
  for Lenalidomide treatment.Pomacel 2mg is used
  in combination with dexamethasone.

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• INDICATION
• The major therapeutic indication of Pomacel
  2mg is involved in the treatment of multiple
  myeloma. This treatment is occurred by combining
  with dexamethasone for reducing the side effect
  associated with Pomacel 2mgomide.Pomacel 2mg is
  majorly indicated in patients who are not reacts
  for prior two therapies like Lenalidomide
  proteasome inhibitor.

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• DOSAGE ADMINISTRATION
• The prescribed dose of Pomacelin multiple myeloma
  is 4mg should be administered orally as once a
  day on day 1 to 21 of reciprocated 28-day
  cycles.Pomacel 2mg should be concomitant with
  dexamethasone.Pomacel 2mg Capsules should be
  taken with or without food.
• During hematological toxicitiesNeutropeniaANC
  (absolute neutrophils count) lt500/mcl Postpone
  the Pomaceltherapy and provide CBC weeklyANC
  more than or equal to 500/mcl Continue the
  Pomacel3mg daily.

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• ThrombocytopeniaPlatelets count lt25,000/mcL
  postpone the Pomaceltreatment follow the
  CBCgt50,000/mcL continue 3mg of Pomacel
• Pomacel 2mg with potent CYP1A2 inhibitorDuring
  this combination reduce the dose of Pomacelby
  50In renal impairmentInitial dose of Pomacel
  is 3mgIn hepatic impairmentMild to moderate
  condition, an initial dose of Pomacelis 3mg in
  severe condition, the initial dose of Pomacel is
  2mg.

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• WORK AS
• Pomacel 2mg exhibits various activities
  likeAnti-neoplastic activityProhibits
  proliferationPromote apoptosis of hematopoietic
  cancer cellsCo adjuvant with dexamethasone in
  both Lenalidomide sensitive resistant myeloma
  cells to activate the tumor cell apoptosis
• Immuno modulatoryBoosted the T-cells natural
  killer cell mediate immunity. The drug is
  prohibited the formation of pro-inflammatory
  cytokines by monocytes.Anti-angiogenesisInterfe
  re with formation of new vessels and leads to
  inhibit the cell division.

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• WARNING
• There are two major worsening condition may occur
  during the treatment using with Pomacel 2mg.
• Embryo fetal damage Pomacel 2mg Capsules are
  contraindicated to pregnancy period.During the
  treatment, patients avoid to becoming
  pregnant.Use effective contraceptives for
  preventing pregnancy during therapy.
• Venous arterial thromboembolismPatient who
  are receiving Pomacel 2mg Capsules have chance of
  getting deep vein thrombosis, pulmonary embolism,
  myocardial infarction stroke.This type of
  condition should be treated by initiating
  prophylactic anti-thrombotic drugs.The patients
  who are acquiring this condition then
  thromboprophylaxis should be provided

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• DRUG INTERACTION
• Pomalidomide metabolism is mediated by CYP1A2
  CYP3A4.The concomitant use of Pomacel 2mg with
  CYP1A2 drugs like Fluvoxamine causes elevation of
  Cmax AUC of Pomalidomide and concludes as
  increased concentration of Pomacelleads to higher
  extent of adverse effects associated with
  PomalidIn this condition, reduce the dose
  of Pomacel 2mg and recommended.
• CONTRAINDICATION
• Pomacel 2mg should be contraindicated to
  pregnancy lactating women. The pregnancy
  category of Pomacel 2mg is X.

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• SIDE EFFECTS
• More common effects of Pomacel 2mg If taken
  during pregnancy, Severe life-threatening human
  birth defects FatigueWeaknessLow white blood
  cell countAnemiaConstipationNauseaDiarrheaSho
  rtness of breathUpper respiratory
  infectionsBack painFever. 
• Less common effects of Pomacel 2mgNeuropathy Diz
  zinessConfusion

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• CONTACT US
• Phone Number 91-9987711567
• Email ID applepharmaceutical_at_gma
  il.com
• Address Apartment No.304 A Wing, 
  Shiva Shakthi chs lts, JP road, Near apna Bazar,
  Andheri(West), Mumbai- 40058, Maharashtra

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