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Revolade 75mg is mainly indicated for the treatment of patients having lower platelet levels due to chronic immune thrombocytopenia and chronic hepatitis C virus infection @ Apple Pharmaceuticals – PowerPoint PPT presentation

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Title: katherineg2552


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Revolade 75mg tablet Apple pharmaceuticals
  • INDICATION
  • DOSAGEMECHANISM
  • ADMEPRECAUTION
  • DRUG INTERACTION
  • STORAGE
  • MISSED DOSESIDE EFFECTS

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Revolade 75mg tablet Apple pharmaceuticals
  • Revolade 75mg is a prescription drug which is
    used under the supervision of the doctor.
  • Revolade 75mg drug may be used as part of a
    co-administration therapy. Hence drug may require
    fortaking it with other medications.
  • INDICATION
  • Revolade 75mg tablet is mainly indicated for the
    treatment of patients having
  • lower platelet levels due to chronic immune
    thrombocytopenia
  • lower platelet counts due to chronic hepatitis
    C virus infection

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  •  


Revolade 75mg
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DOSAGE
  • Chronic Immune Thrombocytopenia
  • The recommended dose of Revolade 75mg has
    Initial 50 mg PO qDay Adjust dose to achieve
    Control platelet count (Plt) gt50 x 109/L to
    reduces risk of bleeding not to exceed 75
    mg/day


Revolade 75mg
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  • Chronic Hepatitis C-associated Thrombocytopenia
  • The recommended dose of Revolade 75mg has
    Initial 25 mg PO qDay Dose is Adjust in 25 mg
    accretion q2weeks PRN to attain target Plt needed
    to start/control antiviral therapy with pegylated
    interferon and ribavirin not to exceed 100
    mg/day During antiviral therapy, regulate dose to
    stop dose reductions of peginterferon Severe
    Aplastic Anemia
  • First-line therapy Concomitant use with standard
    immunosuppressive therapy, for patients with
    serious aplastic Anemia (SAA) The recommended
    dose of Revolade 75mg tablet 150 mg PO qDay for
    6 months Do not give more than starting dose
    total duration is 6 months
  • Refractory SAA
  • The drug given for this condition who fail to
    respond enough to at least 1 before
    immunosuppressive therapy The recommended dose
    of Revolade 75mg 50 mg PO qDay Adjust dose in
    50-mg accretion q2Weeks PRN to attain target Plt
    50 x 109/L as required not exceed 150 mg/day
    may take up to 16 weeks for hematologic response.

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MECHANISM
  • Eltrombopag belongs to growth factors which
    excite platelet production through the
    thrombopoietin (TPO) receptor.  
  • Eltrombopag is a thrombopoietin nonpeptide
    agonist which have high platelet counts by
    binding to and activating the TPO receptor. It
    stimulates pathways within the cell to raises the
    production and development of marrow progenitor
    (parent) cells to strengthen platelet production.

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ADME
  • Absorption
  • peak plasma concentration is 2-6 hours
  • Distribution
  • highly human plasma protein bounding is gt99 and
    in blood plasma level is 50 to 79
  • Metabolism
  • predominantly metabolised through cleavage,
    oxidation and conjugation with glucuronic acid.
  • Elimination
  • Revolade 75mg eliminated primarily via feces 59,
    along with 31 via renally excreted
  • Half-life of Revolade 75mg healthy patients is
    21-23 hours and idiopathic thrombocytopenic
    purpura is 26-35 hours.

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PRECAUTION
  • The drug causes warning condition call the doctor
    while new medication interaction If other blood
    clot risk factors, then avoid the drug because it
    will high level of platelet counts and blood
    clots.
  • If the patients have cataracts, avoid the drug
    due to the drug effects cataracts and make the
    condition worse.
  • Disease progression warning Avoid using the drug
    while the patients have myelodysplastic syndrome
    (MDS), will increases the risk of death.

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DRUG INTERACTION
  • Revolade 75mg co administration with these drugs
    ezetimibe, glyburide, Olmesartan, repaglinide,
    valsartan, imatinib, irinotecan, lapatinib,
    methotrexate, mitoxantrone, Bosentan,
    sulfasalazine, and topotecan irinotecan leads
    increase of side effects. hence the doctor may
    reduce your dosage of these drugs if required.
  • Revolade 75mg tablet concomitant use with
    Cholesterol-reducing drugs like atorvastatin,
    fluvastatin, rosuvastatin, pravastatin, and
    simvastatin, pitavastatin. Have high side effects
    can contains muscle pain. The doctor may decrease
    the dosage of your cholesterol drugs.
  • Revolade 75mg combination with Antacids,
    vitamins, or supplements which involves Ca, Al,
    Fe, Se, Zn, or Mg. To stop interactions, then
    take Revolade two hours before or four hours
    after administrating any of these products.

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  • STORAGE
  • Store at room temperature 20C and 25C.
  • Discard the left-out medicine if not used within
    30 minutes
  • MISSED DOSE
  • In case of missed dose, patients must consult
    with medical practitioner and follow the
    instructions given by them. thereby missed dose
    should be avoid and follow the regular dosing
    schedule.

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SIDE EFFECTS
  • Lack of appetite
  • flu
  • diarrhoea
  • Urine in dark colour
  • Yellowing of your skin
  • low red blood cells
  • nausea
  • fever
  • weakness
  • pain in head
  • cough

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  • Abdomen swelling
  • Confusion
  • Chest pain
  • Dyspnea
  • Cloudy vision
  • Sensitivity to light
  • Seeing circles around lights
  • Swelling of legs

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CONTACT DETAILS
  • Phone  9987711567
  • Email  applepharmaceutical_at_gmail.com
  • Email  info_at_myapplepharma.com
  • Website  https//myapplepharma.com/eltrombopag-75
    mg.php
  •  
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