RAPACT 10MG TABLETS | EVEROLIMUS | MHP

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RAPACT 10MG TABLETS EVEROLIMUS MHP

• Million Health Pharmaceuticals

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DESCRIPTION

• Rapact 10mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor. It is normally used as an
  immunosuppressant to prevent rejection of organ
  transplants. In a similar fashion to other mTOR
  inhibitors Everolimus' effect is solely on the
  mTORC1 protein and not on the mTORC2 protein.

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Breast carcinoma
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PRESCRIBING INFORMATION

• Rapact 10mg tablet are mainly indicated for the
  treatment of Renal carcinoma.Rapact 10mg
  tablet are mainly indicated for the treatment of
  Breast carcinoma.Rapact 10mg tablet are mainly
  indicated for the treatment of Brain
  carcinoma.Rapact 10mg is also used in various
  advanced stage cancer in stomach, intestines or
  pancreas.

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex which inhibits the
  specific of mTOR.This inhibition decreases the
  activity of effectors downstream, that may cause
  blockage of cell progression from G1 into S
  phase, subsequently causes cell growth arrest and
  apoptosis

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RAPACT 10MG
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PRODUCT DETAILS

• Brand Rapact Ingredients Everolimus Strength
  10mgManufactured Natco Pharma Ltd Package
  10 tablets 

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PHARMACOKINETICS

• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.DISTRIBUTION
• Rapact 10mg human plasma protein bound with the
  range of 74.METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.The
  metabolites of Everolimus

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EXCRETION

• The major route of elimination 5 in urine the
  parent compound has been detected in urine or
  feces. The half-life period of Everolimus is
  relatively 30 hours

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancerThe prescribed
  dosage is rapact 10mg should be taken as a single
  dose.In Brain or intracranial cancerThe
  prescribed dosage of Rapact 10mg is 4.5mg/m2
  orally as a single dose.In pediatricThe usual
  pediatric dosage of Rapact 10mg tablet in brain
  or intracranial tumor is 4.5mg/m2 should be taken
  orally as a single dose. Rapact 10mg
  tablet should be administered with or without
  food.

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV lightSerious infections
• Patients receiving Rapact 10mg have high risk of
  acquiring various infections related to bacteria,
  virus, and fungi. Anti-microbial agents are
  preferred for the suspected patients.Hepatic
  artery thrombosis
• In liver transplant patients, Rapact 10mg therapy
  should not be recommended.

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes .

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DRUG INTERACTION

•  Rapact 10mg interaction with strong inhibitor
  of CYP3A4, or P-gp, leads to cause decreasing the
  efflux of Everolimus and increase the plasma
  concentration of Everolimus. Combination
  of Rapact 10mg with verapamil leads to increasing
  the plasma concentration of Everolimus.
  Combination of Rapact 10mg with Atorvastatin or
  pravastatin causes rhabdomyolysis, due to
  increasing concentration of lipid lowering
  agents. Rapact 10mg combination with strong
  CYP3A4 inducers, causes increasing the exposure
  of Everolimus. Concomitant use of Rapact
  10mg with cyclosporine causes increasing the AUC
  level of Everolimus frequently.

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the Rapact 10mg tablet.

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PREGNANCY

• Pregnancy category C Rapact 10mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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LACTATION

• Breast feeding should not be suggested

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STORAGE

• Rapact 10mg tablet should be kept at 25CKeep
  the tablet away from moisture, heat and
  lightDispense only in original container.

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them. Or the missed
  dose should be avoiding and follow the regular
  dosing schedule.

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OVERDOSAGE

• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT DETAIL

• PHONENO91-9940472902
• EMAILmillionhealthpharmaceuticals_at_gmail.com
• WEBSITE URLhttps//millionpharma.com/rapact-10-mg
  .php