Pomalidomide Pomalid 1mg | Anticancerdrugs | MHP

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Pomalidomide Pomalid 1mg Anticancerdrugs MHP
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POMALID 1MG DEFINE

• Pomalidomide is sold under the brand name Pomalid
  1mg and it belongs to anti neoplastics
  drugs Pomalid 1mg is doable as orally
  bioavailable thalidomide derivative asssociated
  with numerous therapeutic activities such as
  immune modulatory, anti-angiogenesis, anti
  neoplastic. Pomalid 1mg combination with
  dexamethasone will cause liver injury

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POMALID 1MG CLINICAL USE

• The primary indication of Pomalid 1mg is used in
  the treatment of Multiple Myeloma condition. In
  this condition, Pomalid 1mg tablet is used by
  combining with dexamethasone. Pomalid
  1mg capsules are applicable in Previously the
  Patients treated with two treatment such as
  proteasome inhibitor Lenalidomide. Patients who
  are suffered with disease progression
  condition Pomalid 1mg tablet treatment should be
  followed within 60 days in patients who are
  concluded the last treatment.

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POMALID 1MG WORKS AS

• Pomalid 1mg tablet has three primary
  pharmacological activities against cancer cells.
  Pomalidomide includes in the way cancer
  proliferation and provoke the apoptosis of cancer
  cells. Pomalidomide enhance the T cell natural
  killer cells interceding immunity inhibits the
  formation of pro inflammatory cytokines from
  monocytes. Pomalidomide forbid the new cell
  formation. The binding of Pomalidomide to active
  site of targeted cell causes inhibition of
  ubiquitin ligase action.

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ADME PROPERTIES

• The time to high serum concentration of
  Pomalidomide is reaches between 2 to 3 hours. It
  should be administered with or without food.
  Hence No effect of food should be produced
  Volume of distribution of Pomalidomide is between
  62 138L in steady state.
• The Pomalidomide distribution by 67 of serum
  level at after 4 hours of drug intake. human
  plasma protein by bounding range of 12 44.
  Hepatically mediated through CYP1A2, CYP3A4 is
  Pomalidomide is metabolized.

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ADME PROPERTIES

• Pomalidomide clearance value is 7 to 10L/hr.
  Doses are excreted via urine 73 feces 15
  respectively. Doses are excreted as an unchanged
  form via urine 2 feces 8. Pomalidomide half
  life period is 9.5 hours.

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Pomalid 1mg

• Brand  Pomalid 
• Ingredients  Pomalidomide 
• Strength  1mg 
• Manufactured  Natco 
• Package  21 Tablets

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DOSAGE MANAGEMENT

• DURING MULTIPLE MYELOMA MALIGNANCIES
• The dosage recommendation of Pomalid 1mg is 4mg
  should be administered as a single dose for 1 to
  21 days of successive 28 day cycles. Pomalid is
  combined with dexamethasone with low dose.
  Administrate Dexamethasone on day 1, 8, 15 22
  of each 28 day cycle. The prescribed dose of
  dexamethasone is 40mg should be administered the
  patient having weight about 75kg. The
  prescribed dose of dexamethasone is 20mg given
  for patients weight Greater than 75kg

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DOSAGE MANAGEMENT

• DOSAGE ALTERATION DURING HEMATOLOGICAL
  TOXICITIES NEUTROPENIA
• ANC lt500/mcL Pomalid treatment should be
  postponed and check the CBC weekly. ANC
  500/mcL Pomalid therapy should be continued by
  3mg/day For each successive drop lt500/mcL
  Pomalid 1mg should be postponed. ANC 500/mcL
  Continue the Pomalid therapy with 1mg/day.

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THROMBOCYTOPENIA

• Platelets count lt25000/mcL Pomalid therapy
  should be postponed and check CBC Platelets count
  50000/mcL 3mg of Pomalid should be taken daily

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WITH STRONG CYP1A2

• Pomalid combined with CYP1A2 substrates causes
  increasing the plasma concentration of
  Pomalidomide and leads to elevate the risk of
  Pomalidomide.

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IN RENAL DAMAGED PATIENTS

• In severe renal impaired patients, the suggested
  dose of Pomalid is 3mg per day.
• IN HEPATIC IMPAIRED PATIENTS
• The advised dose is 3mg/day in severe
  condition, the suggested dose is 2mg/day given
  for mild to moderate patients.

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Pomalid 1mg

• POMALID 1MG DRUG INTERACTION
• Pomalid 1mg concurrently used with CYP1A2 drugs
  causes increased concentration of Pomalidomide.
  Overcome this problem by reducing the dose
  of Pomalid 1mg during this combination
  therapy.POMALID 1MG CONTRAINDICATION
• Pomalid 1mg is contraindicated to Pregnancy
  Lactation Hypersensitivity reactions produced due
  to patients are contraindicated to the component
  of Pomalid 1mg .POMALID 1MG WARNING
• The most probable worsening condition of Pomalid
  1mg is Venous arterial thromboembolism Embryo
  fetal damage

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Pomalid 1mg
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