AFINITOR 10MG | EVEROLIMUS | MHP

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AFINITOR 10MG EVEROLIMUS MHP

• Million Health Pharmaceuticals

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DESCRIPTION

• Afinitor 10mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor.
• It is normally used as an immunosuppressant to
  prevent rejection of organ transplants. In a
  similar fashion to other mTOR inhibitors
  Everolimus' effect is solely on the mTORC1
  protein and not on the mTORC2 protein.

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Stages of stomach cancer
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PRESCRIBING INFORMATION

• Afinitor 10mg tablet are mainly indicated for the
  treatment of Renal carcinoma.
• Afinitor 10mg tablets are mainly indicated for
  the treatment of Breast carcinoma.
• Afinitor 10mg tablet are mainly indicated for the
  treatment of Brain carcinoma.
• Afinitor 10mg is also used in various advanced
  stage cancer in stomach, intestines or pancreas.

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex whichinhibits the specific
  of mTOR.
• This inhibitiondecreases the activity of
  effectors downstream, that may cause blockage of
  cell progression from G1 into S phase,
  subsequently causes cell growth arrest and
  apoptosis

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AFINITOR 10MG
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PRODUCT DETAILS

• Brand Afinitor Ingredients
  Everolimus Strength 10mgManufactured
  Novartis Package 10 tablets 

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PHARMACOKINETICS

• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.The effect of food with Afinitor
  10mg that with heavy meal Reduction of systemic
  exposure to Afinitor 10mg tablet and the high
  blood plasma concentration by 54.
• DISTRIBUTION
• Afinitor 10mg human plasma protein bound with the
  range of 74.
• METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.
• EXCRETION
• The major route of elimination

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancerThe prescribed
  dosage is 10mg should be taken as a single
  dose.In Brain or intracranial cancerThe
  prescribed dosage of Afinitor 10mg is 4.5mg/m2
  orally as a single dose.

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV light
• Serious infections
• Patients receiving Afinitor 10mg have high risk
  of acquiring various infections related to
  bacteria, virus, and fungi. Anti-microbial agents
  are preferred for the suspected patients.

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• Hepatic artery thrombosis
• In liver transplant patients, Afinitor
  10mg therapy should not be recommended.
• Nephrotoxicity
• Renal function should be monitored frequently
  caution should be taken while usingAfinitor
  10mg  in renal impaired patients.
• Angioedema
• This may have occurred in the patients receiving
  concomitantly Afinitor 10mg  tablet with
  Angiotensin converting enzyme agents

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes .

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DRUG INTERACTION

•  Afinitor 10mg interaction with strong inhibitor
  of CYP3A4, or P-gp, leads to cause decreasing the
  efflux of Everolimus and increase the plasma
  concentration of Everolimus.
• Combination of Afinitor 10mg with verapamil
  leads to increasing the plasma concentration of
  Everolimus. Combination of Afinitor 10mg
  tablet with Atorvastatin or pravastatin causes
  rhabdomyolysis, due to increasing concentration
  of lipid lowering agents. Afinitor
  10mg combination with strong CYP3A4 inducers,
  causes increasing the exposure of Everolimus.

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the Afinitor 10mg tablets

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PREGNANCY

• Pregnancy category C Afinitor 10mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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STORAGE

• Afinitor 10mg tablet should be kept at 25CKeep
  the tablet away from moisture, heat and
  lightDispense only in original container.

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them.Or the missed
  dose should be avoiding and follow the regular
  dosing schedule.

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OVERDOSAGE

• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• PHONE NO91-9940472902
• EMAILmillionhealthpharmaceuticals_at_gmail.com
• WEBSITEURLhttps//millionpharma.com/afinitor-10-m
  g.php