EVERMIL 5MG TABLET | EVEROLIMUS | MHP

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EVERMIL 5MG TABLET EVEROLIMUS MHP

• Million Health Pharmaceuticals

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DESCRIPTION

• Evermil 5mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor.It is normally used as an
  immunosuppressant to prevent rejection of organ
  transplants. In a similar fashion to other mTOR
  inhibitors Everolimus' effect is solely on the
  mTORC1 protein and not on the mTORC2 protein.

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PRESCRIBING INFORMATION

• Evermil 5mg tablet are mainly indicated for the
  treatment of Renal carcinom
• Evermil 5mg  are mainly indicated for the
  treatment of Breast carcinoma.
• Evermil 5mg tablet are mainly indicated for the
  treatment of Brain carcinoma.
• Evermil 5mg is also used in various advanced
  stage cancer in stomach, intestines or pancreas.

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 Renal carcinoma
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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex which inhibits the
  specific of mTOR.This inhibition decreases the
  activity of effectors downstream, that may cause
  blockage of cell progression from G1 into S
  phase, subsequently causes cell growth arrest and
  apoptosis

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PRODUCT  DETAILS

• Brand Evermil Ingredients Everolimus Strengt
  h 5mgManufactured Glenmark
  pharmaceuticals Package 10 tablets 

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PHARMACOKINETICS

• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.The effect of food with Evermil
  5mg that with heavy meal Reduction of systemic
  exposure to Evermil 5mg, and the high blood
  plasma concentration by 54.DISTRIBUTION
• Evermil 5mg human plasma protein bound with the
  range of 74.METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.The
  metabolites of Everolimus

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancerThe prescribed
  dosage is 10mg should be taken as a single
  dose.In Brain or intracranial cancerThe
  prescribed dosage of Evermil  5mg is 4.5mg/m2
  orally as a single dose.In pediatricThe usual
  pediatric dosage of Evermil 5mg tablet in brain
  or intracranial tumor is 4.5mg/m2 should be taken
  orally as a single dose. Evermil 5mg
  tablet should be administered with or without
  food.

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV lightSerious infections
• Patients receiving Evermil 5mg have high risk of
  acquiring various infections related to bacteria,
  virus, and fungi. Anti-microbial agents are
  preferred for the suspected patients.Hepatic
  artery thrombosis
• In liver transplant patients, Evermil 5mg therapy
  should not be recommended. 

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Nephrotoxicity

• Renal function should be monitored frequently
  caution should be taken while using Evermil 5mg
  in renal impaired patients. Angioedema
• This may have occurred in the patients receiving
  concomitantly Evermil 5mg with Angiotensin
  converting enzyme agentsHyperlipidemia
• Patient getting Evermil 5mg with lipid lowering
  drugs causes increasing in plasma concentration
  of these drugs causes hyperlipidemiaInterstitial
  lung disease 
• Occurred in Evermil 5mg tablet  therapy

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes .

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DRUG INTERACTION

•  Evermil 5mg interaction with strong inhibitor
  of CYP3A4, or P-gp, leads to cause decreasing the
  efflux of Everolimus and increase the plasma
  concentration of Everolimus. Combination
  of Evermil 5mg tablet with verapamil leads to
  increasing the plasma concentration of
  Everolimus. Combination of Evermil 5mg with
  Atorvastatin or pravastatin causes
  rhabdomyolysis, due to increasing concentration
  of lipid lowering agents. Evermil 5mg
  tablet combination with strong CYP3A4 inducers,
  causes increasing the exposure of Everolimus.
  Concomitant use of Evermil 5mg with cyclosporine
  causes increasing the AUC level of Everolimus
  frequently. Evermil 5mg tablet is interaction
  with ketoconazole or other CYP3A4 inhibitors
  causes increasing the plasma concentration and
  AUC of Everolimus.

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the Evermil 5mg tablet.

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PREGNANCY

• Pregnancy category C Evermil 5mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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PREGNANCY

• Pregnancy category C Evermil 5mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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STORAGE

• Evermil 5mg tablet should be kept at 25CKeep
  the tablet away from moisture, heat and
  lightDispense only in original container.

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them. Or the missed
  dose should be avoiding and follow the regular
  dosing schedule.

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OVERDOSAGE

• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• PHONE NO91-9940472902
• E-MAILmillionhealthpharmaceuticals_at_gmail.com
• WEBSITE URLhttps//millionpharma.com/evermil-5-mg
  .php