Pomacel 4mg capsules | Pomalidomide | Millionpharma

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Pomacel 4mg capsules Pomalidomide
Millionpharma
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Pomacel 4mg price in India


ANTI-NEOPLASTIC
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DESCRIPTION

• Pomalidomide is sold under the brand name Pomacel
  4mg and it belongs to anti-neoplastic drugs
• Pomacel 4mg is doable as orally bioavailable
  thalidomide derivative associated with numerous
  therapeutic activities such as immune
  modulatory, anti-angiogenesis, anti-neoplastic.
• Pomacel price in India combination with
  dexamethasone will cause liver injury

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MECHANISM OF ACTION

• Pomacel 4mg capsules has three primary
  pharmacological activities against cancer cells.
• Pomalidomide includes in the way cancer
  proliferation and provoke the apoptosis of cancer
  cells.
• Pomalidomide enhance the T cell natural killer
  cells interceding immunity inhibits the
  formation of pro inflammatory cytokines from
  monocytes.
• Pomalidomide forbid the new cell formation. The
  binding of Pomalidomide to active site of
  targeted cell causes inhibition of ubiquitin
  ligase action.

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Pomacel price in india 4mg

• Brand  Pomacel 
• Ingredients  Pomalidomide 
• Strength  4mg
• Manufactured  Glenmark Pharma 
• Package  21 capsules

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PHARMACOKINETICS

• The time to high serum concentration of
  Pomalidomide is reaches between 2 to 3 hours.
• It should be administered with or without food.
  Hence No effect of food should be produced
• Volume of distribution of Pomalidomide is between
  62 138L in steady state.
• The Pomalidomide distribution by 67 of serum
  level at after 4 hours of drug intake.
• human plasma protein by bounding range of 12
  44.
• Hepatically mediated through CYP1A2, CYP3A4 is
  Pomalidomide is metabolized.
• Pomalidomide clearance value is 7 to 10L/hr.
• Doses are excreted via urine 73 feces 15
  respectively.
• Doses are excreted as an unchanged form via urine
  2 feces 8.
• Pomalidomide half-life period is 9.5 hours.

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DOSAGE MANAGEMENT

• During multiple myeloma malignancies
• The dosage recommendation of Pomacel 4mg
  capsules is 4mg should be administered as a
  single dose for 1 to 21 days of successive 28-day
  cycles.
• Pomacel is combined with dexamethasone with low
  dose.
• Administrate Dexamethasone on day 1, 8, 15 22
  of each 28-day cycle.
• The prescribed dose of dexamethasone is 40mg
  should be administered the patient having weight
  about 75kg.
• The prescribed dose of dexamethasone is 20mg
  given for patients weight Greater than 75kg
• Dosage alteration during hematological
  toxicities
• Neutropenia
• ANC lt500/mcL Pomacel price in india treatment
  should be postponed and check the CBC weekly.
• ANC 500/mcL Pomacel side effect therapy
  should be continued by 3mg/day
• For each successive drop lt500/mcL Pomacel 4mg
  should be postponed.
• ANC 500/mcL Continue the Pomacel therapy with
  1mg/day.

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DOSAGE MANAGEMENT

• Thrombocytopenia
• Platelets count lt25000/mcL Pomacel price in
  india therapy should be postponed and check CBC
• Platelets count 50000/mcL 3mg of Pomacel side
  effect should be taken daily
• With strong CYP1A2
• Pomacel combined with CYP1A2 substrates causes
  increasing the plasma concentration of
  Pomalidomide and leads to elevate the risk of
  Pomalidomide.
• In renal damaged patients
• In severe renal impaired patients, the suggested
  dose of Pomacel is 3mg per day.
• In hepatic impaired patients
• The advised dose is 3mg/day in severe
  condition, the suggested dose is 2mg/day given
  for mild to moderate patients.
• The most probable worsening condition of Pomacel
  4mg is
• Venous arterial thromboembolism
• Embryo fetal damage.

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CLINICAL USE

• The primary indication of Pomacel 4mg is used in
  the treatment of Multiple Myeloma condition.
• In this condition, Pomacel 4mg is used by
  combining with dexamethasone.
• Pomacel 4mg capsules are applicable in
• Previously the Patients treated with two
  treatment such as proteasome inhibitor
  Lenalidomide.
• Patients who are suffered with disease
  progression condition
• Pomacel 4mg treatment should be followed within
  60 days in patients who are concluded the last
  treatment.

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DRUG INTERACTION

• Pomacel 4mg price in india concurrently used
  with CYP1A2 drugs causes increased concentration
  of Pomalidomide.Overcome this problem by
  reducing the dose of Pomacel 4mg price in india
  during this combination therapy.

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CONTRAINDICATIONS

• Pomacel price in india is contraindicated to
  Pregnancy LactationHypersensitivity reactions
  produced due to patients are contraindicated to
  the component of Pomacel 4mg.

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PRESCRIPTION

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  regulated pharmacy medicine, takes all
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  prescription medications. By placing the order
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  harma.com will not dispense any prescription
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  qualified Pharmacists. The drug information
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  informative purposes only and this Website is not
  intended to provide diagnosis, treatment or
  medical advice. We are not liable for any adverse
  effects or harm to you as a result of your
  reliance on the information in the Website. 

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PRESCRIPTION

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  Customer or the Caregiver to confirm he/she is
  completely aware of the indications, side
  effects, drug interactions, effects of missed
  dose or overdose of the medicines he/she orders
  from us. It is imperative to seek professional
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  prescription medicines on your behalf.

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FOR MORE INFO

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• WEBSITE URL  https//millionpharma.com/pomacel-4m
  g.php