A Single-Dose HPV Vaccine May Be Effective

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A Single-Dose HPV Vaccine May Be Effective
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With the supply of HPV vaccines dwindling,
doctors and researchers are concerned about what
this means for the spread of the disease.
According to recent projections, there wont be a
sufficient number of HPV vaccine doses available
to meet global demand until at least 2024.
However, new research may provide a possible
solution to the HPV vaccine shortage. In
an OBGYN News article published on May 29, 2019,
follow-up results from major phase 3 randomized
controlled trials of bivalent HPV vaccine in
Costa Rica and quadrivalent vaccine in India were
shared. These trials deliver promising evidence
that a single HPV dose could provide protection
against infection for 11 years or more. Since
children who receive the vaccine at the
recommended age currently receive two doses, this
could potentially double the existing supply.
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In the initial trials, the effectiveness of a
single dose was actually a secondary analysis
from the data collected. Researchers didnt set
out to study a single-dose HPV vaccine option,
but they followed up with subjects who ended up
only receiving a single dose instead of
completing the full vaccine schedule. Therefore,
the results dont support the use of a
single-dose vaccine on a larger scale. Due to the
promising results, however, other studies have
been initiated to provide additional data that
could lead to modifications to official vaccine
recommendations. Follow-up from these studies
found that at four and seven years after a single
dose was administered, the vaccine was just as
effective as a two- or three-dose series in
preventing the two most dangerous types of HPV
(types 16 and 18). The same results were found 11
years after the initial dose.
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HPV serum antibody levels also remained stable in
the single-dose group over the course of 11
years. Although the antibody levels were
significantly lower than in subjects who received
the three-shot series of the vaccine, it appears
that the risk for infection was not higher in the
single-dose group. Although some phase 4 vaccine
effectiveness monitoring studies have shown a
lower rate of effectiveness for a single-dose HPV
vaccine, the data analysis methods for these
trials have been criticized. By grouping children
and young teens with subjects over the age of 17,
who have a much higher likelihood of previous
exposure to HPV through sexual contact, the
results may be skewed. The vaccine does not clear
existing infections or protect against any strain
an individual has already been exposed to, so
its unclear whether infections in these subjects
took place before or after vaccination.
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At HPV Hub, we look forward to the results from
future trials that are specifically targeting the
potential effectiveness of a single-dose HPV
vaccine. In addition to making the vaccine much
easier to administer, a one-dose series would
stretch the current vaccine supply much
further. Visit for more info https//hpvhub.com/
a-single-dose-hpv-vaccine-may-be-effective/
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