Metformin – The most common and famous prescribed medicine

1
Metformin The most common and famous prescribed
medicine
Add15years.com Add15years.in Author (Prof.) Dr.
S. Om Goel, MD/DM From family of doctors from
AIIMS, MAMC Delhi University MD Medicine,
USA DM/Fellowship, USA
2
Metformin The most common and famous prescribed
medicine

• Metformin (1,1-dimethylbiguanide), a biguanide
  derivate and its chemical structure is related to
  guanidine.
• Insulin sensitizer
• Most widely prescribed drug to treat
  hyperglycemia, at least 120 million user
  worldwide.
• Monotherapy in combination with all
  antidiabetic.

www.add15years.com www.add15years.in
3
History

• Metformin was first prepared in 1922 by the
  Dublin chemists
• Jean sterne wasthe first to try metformin on
  humans for the treatment of diabetes.
• He coined the name Glucophage for the drug and
  published his results in 1957.
• Metformin was introduced to the United Kingdom in
  1958, France in 1957, and Canada in 1972.

www.add15years.com www.add15years.in
4
Popular Brands

• Glucophage
• Metformin Hydrochloride ER
• Glumetza
• Rioment
• Fortamet
• Glucophage XR
• Diamin
• Formin
• Met 500
• Bigomet

www.add15years.com www.add15years.in
5
Mechanism of action
Decrease hepatic glucose production
through a mild inhibitions of the mitochondrial
respiratory-chain. Decrease intestinal
absorption of glucose. Anti-oxidative properties
of metformin on endothelial cells
www.add15years.com www.add15years.in
6
Actions of metformin

• Anti-obesity effects
• Decreased appetite
• Increased GLP-1 sections

• Anti-hyperglycemic effects
• Decreased intestinal carbohydrate absorption
• Inhibition of hepatic gluconeogenesis
• Enhancement of insulin-stimulated glucose
  transport in the skeletal muscle.

www.add15years.com www.add15years.in
7
Side Effect

• Metallic taste in the mouth
• Gastrointestinal (anorexia, cough, vomiting,
  abdominal discomfort)
• Vitamin B12 deficiency
• Lactic acidosis
• Reduce appetite
• Fatigue

www.add15years.com www.add15years.in
8
AVAIL OFFER NOW
ADD100RsOFF ADD100OFF
Author (Prof.) Dr. S. Om Goel, MD/DM From family
of doctors from AIIMS, MAMC Delhi University
MD Medicine, USA DM/Fellowship, USA
www.add15years.com www.add15years.in