Prurigo Nodularis Clinical Trials | Vial Trials

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What Is Prurigo Nodularis and Its Treatment or
Management Options?
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• Prurigo nodularis is a chronic disorder of the
  skin that is classically seen as multiple, firm,
  flesh to pink colored papules, plaques, and
  nodules commonly located on the extensor surfaces
  of the extremities. The lesions are very pruritic
  and can occur in any age group.
• Prurigo means itch, and nodularis means nodules.
  The itching caused by PN can be so intense that
  people often scratch themselves to the point of
  bleeding.

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• When the skin is scratched repeatedly, it causes
  injury, and the skin then protects itself by
  creating a thicker layer, which is where the
  nodules come from. This is called the
  itch-scratch cycle. These conditions will
  increase the chances of someone's serious health
  issues. It includes
• Psychological conditions
• Reduced liver or kidney function
• Allergies
• Skin diseases such as
• Eczema
• Bullous Pemphigoid
• Dermatitis Herpetiformis
• It is commonly associated with another disease
  such as atopic dermatitis or any dermatoses
  associated with chronic pruritus. The diagnosis
  is chiefly Prurigo Nodularis clinical trials.

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• Let's look at the best Treatment or Management
  Options for Prurigo Nodular
• Management of Prurigo nodularis requires a
  multifaceted approach. Patients need to be
  educated on practices to reduce scratching of
  lesions, assurance, and diagnosing of underlying
  causes of pruritus. 
• General Care
• If you are suffering from this Prurigo nodularis
  chronic disorder, then you should
• Stay in a cool and comfortable environment.
• Applying emollients multiple times a day to keep
  skin moisturized.
• Use gentle bath soap, shampoo, and other
  cleansers.
• Keep your nails short.
• Wear protective clothing, such as long sleeves,
  shirts, or gloves.
• Keep your scratches covered with bandages.
• Reduce Stress.

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Specific Care

• Antihistamines and Leukotriene Inhibitors
• High dose non sedating antihistamines for daytime
  followed by First-generation sedating
  antihistamines at bedtime. A combination of
  fexofenadine and montelukast gives good results.
  Common adverse reactions to antihistamines are
  drowsiness, dizziness, and weakness.

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• Phototherapy/Excimer
• Phototherapy with PUVA, including bath/topical
  PUVA, long-wavelength ultraviolet A, narrowband
  ultraviolet B, and monochromatic excimer light of
  308 nm, have been used and shown improvement of
  Prurigo nodularis nodules in patients.
• Narrow Band UVB phototherapy results in
  significant improvement in Prurigo nodularis at
  an average dose.
• An excimer laser is more beneficial than topical
  clobetasol.

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Topical and Intralesional Therapy

• Topical, oral, and intralesional corticosteroids
  have all been used in prurigo nodularis to
  decrease inflammation and sense of itching and
  soften and smooth out firm nodules. The
  improvement with corticosteroids is variable, and
  corticosteroids. Intralesional corticosteroid
  (usually triamcinolone acetonide) treatment is
  commonly used in resistant cases to a limited
  extent. Triamcinolone acetonide concentrations as
  low as 2.5 mg/mL may be effective, although more
  scarred pruriginous lesions may require higher
  concentrations. A total dose of 20 mg for adults
  every 3-4 weeks is safe for patients without
  diabetes mellitus or hypertension. An 8-am serum
  cortisol test can be performed if concerns exist
  about adrenal suppression.

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