Zollinger-Ellison Syndrome - Symptoms, Causes, and Treatment

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Zollinger-Ellison Syndrome - Symptoms, Causes,
and Treatment

• - Specialty Care Clinics

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What is Zollinger-Ellison Syndrome?

• Zollinger-Ellison syndrome is an unusual
  condition in which one or more tumors form in
  your pancreas or the upper part of your small
  intestine (duodenum). These tumors, known as
  gastrinomas, secrete large amounts of the hormone
  gastrin, which causes your stomach to produce too
  much acid. The excess acid then results in peptic
  ulcers, as well as diarrhea and other symptoms.
• Zollinger-Ellison syndrome might happen at any
  time in life, but people generally find out they
  are affected between ages 20 and 60. Medications
  to lower stomach acid and cure ulcers are the
  usual treatment for Zollinger-Ellison syndrome.

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Symptoms of Zollinger-Ellison Syndrome

• Signs and symptoms of Zollinger-Ellison syndrome
  might include
•    Abdominal pain
•    Diarrhea
•    Burning, aching, gnawing, or discomfort in
  your upper abdomen
•    Acid reflux and heartburn
•    Burping
•    Nausea and vomiting
•    Bleeding in your digestive tract
•    Unintended weight loss
•    Decreased appetite

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Causes of Zollinger-Ellison Syndrome

• The precise cause of Zollinger-Ellison syndrome
  remains unknown. But the sequence of events that
  happens in Zollinger-Ellison syndrome is clear.
  The syndrome starts when one or more tumors
  (gastrinomas) form in your pancreas or duodenum
  or at other areas like the lymph nodes adjacent
  to your pancreas.
• Your pancreas lies behind and below your stomach.
  It produces enzymes that are important to digest
  food. The pancreas also produces various hormones
  including insulin, a hormone that helps to
  control your blood glucose.
• The digestive juices from the pancreas, liver,
  and gallbladder mix into the duodenum, the part
  of the small intestine next to your stomach. This
  is when digestion reaches its peak.
• The tumors that happen with Zollinger-Ellison
  syndrome consist of cells that release large
  amounts of the hormone gastrin. The increase in
  gastrin causes the stomach to produce far too
  much acid. The excess acid then results in peptic
  ulcers and sometimes diarrhea.

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When should you see a doctor? Consult your
doctor if you have persistent, burning, aching,
or gnawing pain in your upper abdomen,
particularly if you have also been experiencing
nausea, vomiting, and diarrhea. Tell your doctor
if you have used over-the-counter acid-reducing
medications like omeprazole (Prilosec, Zegerid),
cimetidine (Tagamet HB), or famotidine (Pepcid
AC) for long periods of time. These medications
might mask your symptoms, which could delay your
diagnosis. Continue To Read More Click Here
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