helmapazhouhankia -COLOSTRUM

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??? ???? ?????? ??????ProfessorDr Vaziry

• Present by
• Helma.Pazhouhankia

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What is colostrum?

• Colostrum is the pre-milk liquid
• that mothers produce at birth
• Commonly referred to as "baby's first milk" and
  biologic soup
• colostrum is the leftover mixture of materials
  present in the mammary gland and ducts at
  delivery. Colostrum is present in the breast from
  12 to 16 weeks of pregnancy. Colostrum is
  produced for up to 5 days following birth before
  evolving into transitional milk, from 6 to 13
  days, and finally into mature milk from 14 days
  onwards. It is thick and yellow in colour due to
  ß-carotene
• It slowly becomes mixed with newly secreted milk
• yet it differs from mature milk in composition
  and is not as plentiful

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• Breasts produce colostrum beginning during
  pregnancy
• and continuing through the early days of
  breastfeeding.
• This special milk is yellow to orange in color
  and thick and sticky
• yellow in colour due to ß-carotene
• It is low in fat, and high in carbohydrates,
  protein, and antibodies to help keep your baby
  healthy.
• Colostrum is extremely easy to digest, and is
  therefore the perfect first food for your baby.
• It is low in volume!
• but high in concentrated nutrition for the
  newborn.

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• It is full of
• immune-enhancing antibodies
• other important immune factors
• and essential growth factors to ensure health
• and vitality for adults and children.

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Colostrum versus Whole milk
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Colostrum's components

• There are over 90 known components in colostrum.
• The primary components
• divided into two classes
• immune factors
• growth factors.
• Colostrum also contains a precise balance of
• vitamins, minerals and amino acids.
• All of these factors work together in perfect
  synergy to restore and maintain health.

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Colostrum's Immune Factors

• Immune Factors in colostrum have been shown
• to help the body fight off harmful invaders such
  as viruses, bacteria, yeast and fungus. Each
  factor plays a specific role in our bodys defense
• against these attackers.
• In addition, colostrum contains over 20
  antibodies
• to specific pathogens including E coli,
  salmonella, rotavirus, candida, streptococcus,
  staphylococcus, H pylori, and cryptosporidia.
• In addition to immunoglobulins, medical studies
  show that PRP in colostrum also supports an under
  active immune system. PRP also helps balance an
  overactive immune system present in autoimmune
  diseases

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Colostrums Growth Factors

• Growth Factors help build and restore bone,
  muscle, nerve tissue, connective tissue, skin and
  cartilage.
• These factors have also been shown to help
  increase lean muscle,
• help the body burn fat for fuel,
• and assist in wound healing.
• Growth factors have also been shown to help slow
  the signs of aging

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Colostrums growth factors may

• Affect the brain's mood regulating chemicals to
  brighten our moods. (Serotonin dopamine)
• Assist in regeneration and improve normal growth
  of aged or injured muscle,bone, cartilage, skin
  collagen and nerve tissue.
• Help burn fat for fuel instead of muscle tissue
  in times of fasting (diet), and build retain
  lean muscle (non-diet).
• Assist the internal regulation of blood glucose
  levels and "brain chemicals", supporting
  alertness and better concentration.
• Support healing skin when applied topically ?
  Repair our body's precious RNA and DNA

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Other Beneficial Components

• Vitamins and Minerals are nutrients that are
  essential for normal metabolism, growth and
  development.
• They act as coenzymes, enabling chemical process
  to take place throughout the body.
• Vitamins and minerals are indispensable for the
  maintenance of health
• Amino Acids are required for growth and
  development. Amino acids are divided into
  essential (not produced by the body) and
  nonessential (can be produced by the body).

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Known Components of Bovine Colostrum

• Immune Factors - Immunoglobulins
• Antibodies
• IgG - Neutralizes toxins and other invaders
  including viruses and bacteria
• IgM - Destroys bacteria, controls antibody
  response ? IgD - Antiviral, prevents hemolytic
  disease in infants
• IgE - Involved in regulating allergic response
• IgA - Highly antiviral and antibacterial,
  prevents infection
• Secretory IgA (SigA) - Found in mucous membranes,
  helps protect against infectionIgA Specific
  Helper - Stimulates the production of IgA

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Antibody Structure
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Antibodies Classification
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• Lactoferrin - Powerful antioxidant, antiviral,
  antibacterial, anti-inflammatory
• Lactoferrin-Fe - Iron chelator
• Transferrin - Binds and transports iron
• Glycoproteins
• (Including Protease and Trypsin Inhibitors)
  Protect components from destruction by stomach
  acids
• Lactalbumin - Raises brain serotonin levels,
  improves mood under stress
• Multimeric a-Lactalbumin - Shown to cause lung
  cancer cells to create selective suicide
  (apoptopsis)

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• Cytokines
• (Including Interleukins, Interferon Y, Tumor
  Necrosis Factor (TNF), and Lymphokines)
  Antiviral, anti-tumor (stimulates death of some
  tumors), increase T-cell activity, responsible
  for regulation and intensity of immune response,
  stimulate production of immunoglobulins
• Proline-Rich Polypeptide (PRP)
• Regulates the activity of the immune system
• Lysozymes Help protect body from bacterial
  infection, topical antibiotic
• Gamma Globulin - Resists infection
• B Lactoglobulin - Antibody, protein
• Complement 3 4 (C3 C4) - Proteins that
  activate the complement of the immune system
• Kappa Casein - Glycoprotein that protects against
  the bacteria that causes stomach ulcers
• Alpha 2-AP glycoprotein
• Alpha 1- antitrypsin - Inhibitor of trypsin
• Alpha 2- macroglobulin - Function as hormonal
  transporters
• Orosomucoids - Alpha-1 protein in plasma ?
  Prealbumin - Precursor to albumin
• Albumin - Contains essential amino acids
• Oligosaccharides - Complex carbohydrates, help
  prevent lung inflammations and ear infection
• Non Specific Inhibitors (NSI's) - Factors that
  inhibit a wide range of respiratory illness

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Growth Factors

• Epithelial Growth Factor (EGF) - Helps protect
  and maintain the skin
• Fibroblast Growth Factor (FGF) - Enhances wound
  healing and tissue repair
• Insulin-like Growth Factor I (IGF-I) - Increases
  lean muscle mass, helps repair DNA and RNA,
  anti-aging, may regulate blood-sugar and
  cholesterol levels
• Insulin-like Growth Factor II (IGF-II) - Affects
  how the body uses fat and protein
• Growth Hormone (GH) - Regulates growth, decreases
  signs of aging
• Transforming Growth Factor - a (TGF- a) - Assists
  in formation and healing of connective tissue,
  bone and cartilage
• Transforming Growth Factor - b (TGF - b) - Helps
  repair tissue, supports growth of the lining of
  the gut. Shown to produce cell destruction in
  certain human cancers.
• Platelet-Derived Growth Factor (PDGF) -
  Stimulates growth of connective tissue, plays a
  role in wound healing and helps with cell
  division and neuron survival and regeneration
• Gonadotropin-Releasing Hormone (GnRH) -
  Stimulates release of follicle-stimulating
  hormone, gonadotropic substances and treats
  endometriosis
• Prolactin - Similar to Growth Hormone ? Insulin
  - Responsible for proper metabolism of blood
  sugar

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Vitamins and Other Nutrients

• Vitamin B6 - Produces serotonin, utilization of
  amino acids ? Vitamin
• B12 - Normal development of red blood cells
• Vitamin E - Antioxidant, supports wound healing
  and immune function
• Vitamin A (from carotene) - Resistance to
  infections, maintains cell integrity
• Vitamin C - Antioxidant, immune system support
• Thiamin (Vitamin B1) - Metabolism of
  carbohydrates, energy
• Folic Acid - Cell replication and tissue growth

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• Pantothenic Acid - Metabolism of fats,
  carbohydrates and protein
• Riboflavin (Vitamin B2) - Energy production,
  tissue repair, healthy eyes
• Beta-carotene - Antioxidant
• Glycoconjugates - Carbohydrates that link to
  lipids and proteins
• Glycogen - Converts into glucose when needed by
  tissues
• Retinoic Acid - Metabolite of Vitamin A, used in
  treatment of acne

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Minerals

• Calcium - Maintains strong, healthy bones,
  activates enzymes
• Chromium - Glucose metabolism disorders, body fat
  reduction
• Iron - Oxygen transport and storage, energy,
  immune support
• Magnesium - Muscle relaxation, assists with
  psychiatric disorders
• Phosphorus - Strengthens bones and teeth
• Potassium - Lowers blood pressure, maintains
  fluid balance in cells
• Sodium - Cell membrane integrity, plays important
  role in nerve function
• Zinc - Synthesis of DNA and RNA, activates
  Vitamin A

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Essential Amino Acids

• Isoleucine - Assists in muscle development
  repair, helps regulate blood sugar
• Leucine - Involved in muscle repair, wound
  healing and hormone production
• Histidine - Involved in growth and tissue repair
• Methionine - Antioxidant, collagen synthesis,
  helps prevent arterial fat buildup
• Lysine - Aids in calcium absorption, helps
  regulate antibody and enzyme production
• Threonine - Stimulates antibody production
• Phenylalanine - Assists neurotransmitter
  function, increases "feel good" chemicals in
  brain
• Valine - Regulates energy, aids growth and repair
  of muscle tissue
• Tryptophan - Stimulates niacin production,
  precursor for serotonin

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Nonessential Amino Acids

• Arginine - Stimulates GH, immune function,
  promotes wound healing and muscle growth
• Cystine - An antioxidant involved in collagen
  synthesis
• Glutanic Acid - Helps transport potassium to the
  brain, implicated in neurological conditions
• Alanine - Involved in glucose metabolism
• Tyrosine - Regulate mood, may improve memory,
  appetite suppressant
• Glycine - Helps decrease muscle wasting, aids in
  glycogen storage
• Proline - Aids in wound healing and collagen
  synthesis
• Aspartic Acid - Helps synthesis of DNA, RNA, Ig
  and antibodies, involved in energy metabolism
• Serine - Involved in fat metabolism and muscle
  growth, noted moisturizer

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Additional Factors Found in Colostrum

• Beta 2- microglobulin - Components of many cell
  membranes including leukocytes
• Enzymes - Induce chemical changes in the body
• Haemopexin - Iron-binding protein
• Haptoglobulin - Glycoproteins that aid the
  recycling of iron
• Lactoperoxidase - An antioxidant
• Orotic Acid - Precursor to certain nucleotides
• Peroxidase - Transfers oxygen to tissues, helps
  prevent free radical damage
• Xanthine Oxidase Enzyme - Enzyme involved in
  conversion of hypoxanthine to xanthine
• Lactobacillus Acidophilus, Bifidobacterium,
  Lactobacillus Bifidus - Help restore a supportive
  bacterial environment in the body

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How Does Colostrum Work

• Colostrum is highly beneficial in the unique
  manner in which it provides the body with its
  numerous immune and growth factors.
• Most infectious disease-causing organisms enter
  the body through the mucous membranes of the
  intestinal tract.
• In order to remain healthy, it is critical that
  we are able to combat disease-causing organisms,
  such as bacteria and viruses,as well as
  environmental toxins, contaminants and allergens
  where they attack us
• Clinical research by Dr. David Tyrell in
  England, published in 1981, revealed that a high
  percentage of the antibodies and immunoglobulins
  present in colostrum are believed not to be
  absorbed but remain in the intestinal tract where
  they attack disease causing organisms before they
  can penetrate the body and cause disease. The
  remainder are absorbed and distributed to assist
  in our internal defense processes. It is this
  combination of action that makes colostrum as
  unique and effective as an oral supplement.

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Reference

• Cellular and Molecular Immunology 10th Edition -
  February 19, 2021 Authors Abul Abbas, Andrew
  Lichtman, Shiv Pillai Paperback ISBN
  9780323757485
• Postpartum and early neonatal careIan Symonds MB
  BS MMedSci DM FRCOG FRANZCOG, in Essential
  Obstetrics and Gynaecology, 2020
• A proline-rich polypeptide from ovine colostrum
  colostrinin with immunomodulatory
  activity.Zimecki M. Adv Exp Med Biol. 2008. PMID
  18183932 Review.
• Health Medicine May. 11, 2013 12,971
• colostrum references along with doctor's review
  on bovine Chintan ChavdaChintan
  ChavdaFollowProduct Manager at Gujarat Terce
  Laboratories Ltd

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• www.llli.org/faq/colostrum.html 2.
  www.colostrummax.com/shop2012/index.php?routeinf
  ormation/informationinformation_id10 3.
• www.thefinchleyclinic.com/shop/what-colostrum-a-5
  19.html 5.
• http//www.olisticgastroenterology.com/probiotic
  s-and-colostrum
• www.icnr.org/home-page/colostrum-is-safe-and-effe
  ctive-what-one-of-the-worlds-leading-physicians-ha
  s-to-say.html 7. www.exrx.net/Nutrition/Supplemen
  ts/BovineColostrum.html 8. www.colostrum.co/colos
  trum_question.htm