Undifferentiated Pleomorphic Sarcoma - Symptoms, Causes, and Treatment

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Undifferentiated Pleomorphic Sarcoma - Symptoms,
Causes, and Treatment

• - Specialty Care Clinics

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What is Undifferentiated Pleomorphic Sarcoma?

• Undifferentiated pleomorphic sarcoma (UPS) is a
  rare type of cancer that starts mostly in the
  soft tissues of the body. Soft tissues join,
  support, and surround other body structures.
• UPS generally happens in the arms or legs. Less
  often it could happen in the area behind the
  abdominal organs (retroperitoneum).
• The name undifferentiated pleomorphic sarcoma
  comes from how cancer cells appear under the
  microscope. Undifferentiated means the cells do
  not look like the body tissues in which they
  develop. The cancer is known as pleomorphic
  because the cells grow in multiple shapes and
  sizes.
• Treatment for UPS depends upon the location of
  cancer but usually involves surgery, radiation,
  and drug treatments.
• UPS used to be known as malignant fibrous
  histiocytoma.

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Symptoms of Undifferentiated Pleomorphic Sarcoma

• Undifferentiated pleomorphic sarcoma symptoms
  depend on where cancer happens. It most usually
  occurs in the arms and legs, but it could occur
  anywhere in the body.
• Signs and symptoms might include
• Growing lump or area of swelling
• If it grows very large, there might be pain,
  tingling, and numbness
• If it happens in an arm or leg, there might be
  swelling in the hand or foot of an affected limb
• If it happens in the abdomen, there might be a
  pain, loss of appetite, and constipation
• Fever
• Weight loss

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Causes of undifferentiated pleomorphic sarcoma

• It is not clear what causes undifferentiated
  pleomorphic sarcoma.
• Doctors know this cancer starts when a cell
  develops changes in its DNA. A cell's DNA
  consists of the instructions that tell a cell
  what to do. The changes tell the cell to multiply
  quickly, creating a mass of abnormal cells
  (tumor). The cells could invade and destroy
  nearby healthy tissue. In time, the cancer cells
  could break away and spread (metastasize) to
  other parts of the body, like the lungs and
  bones.
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