Title: How Are Pharmaceutical Tablets Manufactured at JoinHub Pharma
1(No Transcript)
2How Are Pharmaceutical Tablets Manufactured at
JoinHub Pharma?
- The design and manufacturing of pharmaceutical
tablets is a complex and multi-stage process. The
formulation experts at JoinHub Pharma ensure that
the correct amount of drug substance in the
suitable form is delivered at the appropriate
time, reasonable rate, and at the desired
location with its chemical integrity protected to
the extreme point. - Many drug substances do not possess the required
properties, which give adequate flow from the
hopper to the die cavity of tablet presses. Thus,
they are subjected to pre-treatment either alone
or in combination with suitable excipients to
form free-flowing granules that lend themselves
to tableting. - As a leading pharmaceutical tablet manufacturer,
we at JoinHub Pharma manufacture tablets by wet
granulation, dry granulation, or direct
compression. These tablet manufacturing processes
consist of a number of steps, including weighing,
mixing, granulation, milling, drying, compaction,
often coating, and packaging. The unit processes
milling, weighing, and mixing- are the same
subsequent steps differ regardless of which
method is utilized.
3Primary Goals of JoinHub Pharmas Tablet
Manufacturing Process
- The primary goals include
- To formulate solid and hard tablets to resist
mechanical shock encountered during production,
packing, shipping, dispensing, and utilization. - To formulate tablets that are uniform in drug
content and weight. - To formulate tablets that are bioavailable as per
the indication requirements. - To formulate tablets that are physically and
chemically stable over a long period. - To formulate tablets with an elegant product
identity free from any tablet defects.
4Categories of Pharma Tablet for Oral Use
- Coated tablets
- Uncoated tablets
- Gastro-resistant tablets
- Soluble tablets
- Modified-release tablets
- Dispersible tablets
- Oral lyophilisates
- Chewable tablets
5How Tablets Are Manufactured at JoinHub Pharma
- A tablet is a dosage form comprising a mixture of
active substances and excipients in powder form
in the pharmaceutical jargon. - The ingredients pass through a series of
processes and compact into a solid dose. The
excipients are - Binders
- Diluters
- Glidants
- Lubricants
- The disintegrators are included to help break the
pharma tablet into the digestive tract.
Sometimes, flavors or sweeteners are added to
make the tablet palatable. Polymer coating makes
swallowing easy and controls an active
ingredients release rate. It makes the tablet
more environment-resistant.
6Steps Involved in Pharmaceutical Tablet
Manufacturing
- All pharmaceutical tablets are manufactured in
JoinHub Pharmas WHO-GMP certified manufacturing
units located in Ahmedabad. - Dispensing
- Each ingredient in the tablet formula is weighed
and precisely dispensed as per dose. This is
considered as one of the critical steps in any
type of formulation process and is done by our
technical experts. - Sizing
- Formulation ingredients are equally separated in
form otherwise, reducing size needs to be
carried out for better flow property and easy
mixing.
7Steps Involved in Pharmaceutical Tablet
Manufacturing
- Powder Blending
- Powders are mixed utilizing a suitable blender to
get a uniform and homogeneous powder mix.
Further, the drug substance and excipients are
blended in geometric dilution. - Granulation
- At this stage, tiny powder particles are gathered
into layers and permanent aggregates to induce
them into free-flowing forms. - Drying and Dry Screening
- Screened wet granules are dried for a particular
period in a tray dry or fluid bed dryer at a
controlled temperature not more than 550C. Dried
granules are screened via the appropriate mesh
screen.
8Steps Involved in Pharmaceutical Tablet
Manufacturing
- Tablet Compression
- This step includes compression granules into flat
or convex, oblong, round, or unique shaped,
scored, or unscored tablets engraved with a
recognized symbol and/ or code number using a
tablet press. - Coating
- Granules and tablets are coated if there is a
need to mask the unpleasant taste/odor of some
drug substance or increase the aesthetic look of
uncoated tablets and modify the release or
control the release drug substance from tablets.
This is accomplished by enclosing or covering the
primary tablet or granules with coating solutions.
9Packaging and Storing of Tablets
- Before sending out tablets to the distributor,
they are generally packaged using the latest
packaging techniques and materials. The type of
packaging material utilized is superior. We
choose the material based on several factors,
including - Compatibility of the material with the
formulation. - The degree of protection required.
- Presentation, especially for those pharma
products which may be the subject of impulse
buying - Customer convenience in terms of weight, size,
method of opening or reclosing, legibility of
printing, etc. - Filling Method and
- Cost
10Types of Tablet Packaging
Our top-notch pharma product packaging provides
excellent environmental protection for each
tablet unit, coupled with an aesthetically
pleasing and productive appearance. At JoinHub
Pharma, pharmaceutical tablets are typically
packed using blister and strip packs and are kept
in low humidity and save from extreme
temperatures. Blister and strip packaging
additionally offer some degree of tamper
resistance to the dosage form.
Blister Packaging Tablets This is a universal
term for preformed plastic packaging for
pharmaceuticals tablets. The major element of the
blister pack is in the thermoformed plastic. It
has a fundamental tablet packaging that will
envelop the product and keep it in place. The
main components of the blister packs are the
cavity and the lidding.
11We will then cover it with secondary packaging
for grouping all primary packages in one place.
It further has an aluminum leading foil,
paperboard backing, or plastic seal. You may also
use a clamshell, a type of blister that folds
onto itself. We use the blister packages for
unit packaging of doses.
Bottle Packaging of Tablets We place the tablets
in a bottle which is the primary package. After
that, we cover the bottle with a lid which acts
as the secondary package. This type of tablet
packaging is used for very strong tablets that
cannot break easily. After packaging the tablets
in either the blister package or bottle package,
we place them in a tertiary package like boxes
for bulk handling.
12Let us proceed to the last section of this guide,
covering the quality control tests. For larger
quantities delivered to the pharmacist, plastic
or glass bottles, cartons, metal containers, or
paperboard drums are used along with polyethylene
liners, whenever required, to provide extra
protection from moisture. If cotton wool
stuffing is used under these circumstances, we
use external liners so that any moisture it
contains does not gain access to the tablets.
Tablets that are decomposed when exposed to
moisture are packaged with a desiccant packet.
Light-sensitive tablets are packaged in
light-resistant containers. With just a couple of
exemptions, tablets that are well stored will
remain stable for many years.
13Joinhub Pharma A Leading Pharmaceutical Tablet
Manufacturer
- An ISO Certified Third-Party Pharmaceutical
tablet manufacturing Company adheres to WHO, and
GMP Guidelines have a Trusted name in providing
Third-Party Manufacturing services for Tablets. - Being the Best Pharmaceutical Tablets
Manufacturer in India, we offer to manufacture
all Tablets segments such as analgesics,
antibiotics, antiemetics, anti-infectives,
anti-allergic, local anesthesia,
anti-inflammatory, etc. We Manufacture tablets
intending to be uniform in drug content and
weight, chemically really stable and free of
defects. Also, it uses the latest packaging
technologies Flexible selection of more modern
and venerable science. - We always focus on manufacturing pharma tablets
that are effective and hard to resist several
movements without breaking yet become an easy
solution in dissolution. - Looking for the best pharmaceutical tablet
manufacturer and supplier in Latin America, South
Africa, and Middle East?
14- Want quality pharmaceuticals tablets drug/
medicines range? Look no further than JoinHub
Pharma The top pharmaceuticals tablets
manufacturer in India that brings total quality
controls, Schedule M units, best packaging
technique, skilled brains, and quick distribution
chains, all under one roof. - Reach out to our pharma experts today by just
dropping an email at info_at_joinhubpharma.com
15Contact Us Today For All Your Requirement Related
To Pharmaceutical Products