How Are Pharmaceutical Tablets Manufactured at JoinHub Pharma

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How Are Pharmaceutical Tablets Manufactured at
JoinHub Pharma?

• The design and manufacturing of pharmaceutical
  tablets is a complex and multi-stage process. The
  formulation experts at JoinHub Pharma ensure that
  the correct amount of drug substance in the
  suitable form is delivered at the appropriate
  time, reasonable rate, and at the desired
  location with its chemical integrity protected to
  the extreme point.
• Many drug substances do not possess the required
  properties, which give adequate flow from the
  hopper to the die cavity of tablet presses. Thus,
  they are subjected to pre-treatment either alone
  or in combination with suitable excipients to
  form free-flowing granules that lend themselves
  to tableting.
• As a leading pharmaceutical tablet manufacturer,
  we at JoinHub Pharma manufacture tablets by wet
  granulation, dry granulation, or direct
  compression. These tablet manufacturing processes
  consist of a number of steps, including weighing,
  mixing, granulation, milling, drying, compaction,
  often coating, and packaging. The unit processes
  milling, weighing, and mixing- are the same
  subsequent steps differ regardless of which
  method is utilized.

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Primary Goals of JoinHub Pharmas Tablet
Manufacturing Process

• The primary goals include
• To formulate solid and hard tablets to resist
  mechanical shock encountered during production,
  packing, shipping, dispensing, and utilization.
• To formulate tablets that are uniform in drug
  content and weight.
• To formulate tablets that are bioavailable as per
  the indication requirements.
• To formulate tablets that are physically and
  chemically stable over a long period.
• To formulate tablets with an elegant product
  identity free from any tablet defects.

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Categories of Pharma Tablet for Oral Use

• Coated tablets
• Uncoated tablets
• Gastro-resistant tablets
• Soluble tablets
• Modified-release tablets
• Dispersible tablets
• Oral lyophilisates
• Chewable tablets

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How Tablets Are Manufactured at JoinHub Pharma

• A tablet is a dosage form comprising a mixture of
  active substances and excipients in powder form
  in the pharmaceutical jargon.
• The ingredients pass through a series of
  processes and compact into a solid dose. The
  excipients are
• Binders
• Diluters
• Glidants
• Lubricants
• The disintegrators are included to help break the
  pharma tablet into the digestive tract.
  Sometimes, flavors or sweeteners are added to
  make the tablet palatable. Polymer coating makes
  swallowing easy and controls an active
  ingredients release rate. It makes the tablet
  more environment-resistant.

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Steps Involved in Pharmaceutical Tablet
Manufacturing

• All pharmaceutical tablets are manufactured in
  JoinHub Pharmas WHO-GMP certified manufacturing
  units located in Ahmedabad.
• Dispensing
• Each ingredient in the tablet formula is weighed
  and precisely dispensed as per dose. This is
  considered as one of the critical steps in any
  type of formulation process and is done by our
  technical experts.
• Sizing
• Formulation ingredients are equally separated in
  form otherwise, reducing size needs to be
  carried out for better flow property and easy
  mixing.

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Steps Involved in Pharmaceutical Tablet
Manufacturing

• Powder Blending
• Powders are mixed utilizing a suitable blender to
  get a uniform and homogeneous powder mix.
  Further, the drug substance and excipients are
  blended in geometric dilution.
• Granulation
• At this stage, tiny powder particles are gathered
  into layers and permanent aggregates to induce
  them into free-flowing forms.
• Drying and Dry Screening
• Screened wet granules are dried for a particular
  period in a tray dry or fluid bed dryer at a
  controlled temperature not more than 550C. Dried
  granules are screened via the appropriate mesh
  screen.

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Steps Involved in Pharmaceutical Tablet
Manufacturing

• Tablet Compression
• This step includes compression granules into flat
  or convex, oblong, round, or unique shaped,
  scored, or unscored tablets engraved with a
  recognized symbol and/ or code number using a
  tablet press.
• Coating
• Granules and tablets are coated if there is a
  need to mask the unpleasant taste/odor of some
  drug substance or increase the aesthetic look of
  uncoated tablets and modify the release or
  control the release drug substance from tablets.
  This is accomplished by enclosing or covering the
  primary tablet or granules with coating solutions.

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Packaging and Storing of Tablets

• Before sending out tablets to the distributor,
  they are generally packaged using the latest
  packaging techniques and materials. The type of
  packaging material utilized is superior. We
  choose the material based on several factors,
  including
• Compatibility of the material with the
  formulation.
• The degree of protection required.
• Presentation, especially for those pharma
  products which may be the subject of impulse
  buying
• Customer convenience in terms of weight, size,
  method of opening or reclosing, legibility of
  printing, etc.
• Filling Method and
• Cost

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Types of Tablet Packaging
Our top-notch pharma product packaging provides
excellent environmental protection for each
tablet unit, coupled with an aesthetically
pleasing and productive appearance. At JoinHub
Pharma, pharmaceutical tablets are typically
packed using blister and strip packs and are kept
in low humidity and save from extreme
temperatures. Blister and strip packaging
additionally offer some degree of tamper
resistance to the dosage form.
Blister Packaging Tablets This is a universal
term for preformed plastic packaging for
pharmaceuticals tablets. The major element of the
blister pack is in the thermoformed plastic. It
has a fundamental tablet packaging that will
envelop the product and keep it in place. The
main components of the blister packs are the
cavity and the lidding.
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We will then cover it with secondary packaging
for grouping all primary packages in one place.
It further has an aluminum leading foil,
paperboard backing, or plastic seal. You may also
use a clamshell, a type of blister that folds
onto itself. We use the blister packages for
unit packaging of doses.
Bottle Packaging of Tablets We place the tablets
in a bottle which is the primary package. After
that, we cover the bottle with a lid which acts
as the secondary package. This type of tablet
packaging is used for very strong tablets that
cannot break easily. After packaging the tablets
in either the blister package or bottle package,
we place them in a tertiary package like boxes
for bulk handling.
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Let us proceed to the last section of this guide,
covering the quality control tests. For larger
quantities delivered to the pharmacist, plastic
or glass bottles, cartons, metal containers, or
paperboard drums are used along with polyethylene
liners, whenever required, to provide extra
protection from moisture. If cotton wool
stuffing is used under these circumstances, we
use external liners so that any moisture it
contains does not gain access to the tablets.
Tablets that are decomposed when exposed to
moisture are packaged with a desiccant packet.
Light-sensitive tablets are packaged in
light-resistant containers. With just a couple of
exemptions, tablets that are well stored will
remain stable for many years.
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Joinhub Pharma A Leading Pharmaceutical Tablet
Manufacturer

• An ISO Certified Third-Party Pharmaceutical
  tablet manufacturing Company adheres to WHO, and
  GMP Guidelines have a Trusted name in providing
  Third-Party Manufacturing services for Tablets.
• Being the Best Pharmaceutical Tablets
  Manufacturer in India, we offer to manufacture
  all Tablets segments such as analgesics,
  antibiotics, antiemetics, anti-infectives,
  anti-allergic, local anesthesia,
  anti-inflammatory, etc. We Manufacture tablets
  intending to be uniform in drug content and
  weight, chemically really stable and free of
  defects. Also, it uses the latest packaging
  technologies Flexible selection of more modern
  and venerable science.
• We always focus on manufacturing pharma tablets
  that are effective and hard to resist several
  movements without breaking yet become an easy
  solution in dissolution.
• Looking for the best pharmaceutical tablet
  manufacturer and supplier in Latin America, South
  Africa, and Middle East?

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• Want quality pharmaceuticals tablets drug/
  medicines range? Look no further than JoinHub
  Pharma The top pharmaceuticals tablets
  manufacturer in India that brings total quality
  controls, Schedule M units, best packaging
  technique, skilled brains, and quick distribution
  chains, all under one roof.
• Reach out to our pharma experts today by just
  dropping an email at info_at_joinhubpharma.com

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