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How Are Pharmaceutical Tablets Manufactured at JoinHub Pharma

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Title: How Are Pharmaceutical Tablets Manufactured at JoinHub Pharma


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How Are Pharmaceutical Tablets Manufactured at
JoinHub Pharma?
  • The design and manufacturing of pharmaceutical
    tablets is a complex and multi-stage process. The
    formulation experts at JoinHub Pharma ensure that
    the correct amount of drug substance in the
    suitable form is delivered at the appropriate
    time, reasonable rate, and at the desired
    location with its chemical integrity protected to
    the extreme point.
  • Many drug substances do not possess the required
    properties, which give adequate flow from the
    hopper to the die cavity of tablet presses. Thus,
    they are subjected to pre-treatment either alone
    or in combination with suitable excipients to
    form free-flowing granules that lend themselves
    to tableting.
  • As a leading pharmaceutical tablet manufacturer,
    we at JoinHub Pharma manufacture tablets by wet
    granulation, dry granulation, or direct
    compression. These tablet manufacturing processes
    consist of a number of steps, including weighing,
    mixing, granulation, milling, drying, compaction,
    often coating, and packaging. The unit processes
    milling, weighing, and mixing- are the same
    subsequent steps differ regardless of which
    method is utilized.

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Primary Goals of JoinHub Pharmas Tablet
Manufacturing Process
  • The primary goals include
  • To formulate solid and hard tablets to resist
    mechanical shock encountered during production,
    packing, shipping, dispensing, and utilization.
  • To formulate tablets that are uniform in drug
    content and weight.
  • To formulate tablets that are bioavailable as per
    the indication requirements.
  • To formulate tablets that are physically and
    chemically stable over a long period.
  • To formulate tablets with an elegant product
    identity free from any tablet defects.

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Categories of Pharma Tablet for Oral Use
  • Coated tablets
  • Uncoated tablets
  • Gastro-resistant tablets
  • Soluble tablets
  • Modified-release tablets
  • Dispersible tablets
  • Oral lyophilisates
  • Chewable tablets

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How Tablets Are Manufactured at JoinHub Pharma
  • A tablet is a dosage form comprising a mixture of
    active substances and excipients in powder form
    in the pharmaceutical jargon.
  • The ingredients pass through a series of
    processes and compact into a solid dose. The
    excipients are
  • Binders
  • Diluters
  • Glidants
  • Lubricants
  • The disintegrators are included to help break the
    pharma tablet into the digestive tract.
    Sometimes, flavors or sweeteners are added to
    make the tablet palatable. Polymer coating makes
    swallowing easy and controls an active
    ingredients release rate. It makes the tablet
    more environment-resistant.

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Steps Involved in Pharmaceutical Tablet
Manufacturing
  • All pharmaceutical tablets are manufactured in
    JoinHub Pharmas WHO-GMP certified manufacturing
    units located in Ahmedabad.
  • Dispensing
  • Each ingredient in the tablet formula is weighed
    and precisely dispensed as per dose. This is
    considered as one of the critical steps in any
    type of formulation process and is done by our
    technical experts.
  • Sizing
  • Formulation ingredients are equally separated in
    form otherwise, reducing size needs to be
    carried out for better flow property and easy
    mixing.

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Steps Involved in Pharmaceutical Tablet
Manufacturing
  • Powder Blending
  • Powders are mixed utilizing a suitable blender to
    get a uniform and homogeneous powder mix.
    Further, the drug substance and excipients are
    blended in geometric dilution.
  • Granulation
  • At this stage, tiny powder particles are gathered
    into layers and permanent aggregates to induce
    them into free-flowing forms.
  • Drying and Dry Screening
  • Screened wet granules are dried for a particular
    period in a tray dry or fluid bed dryer at a
    controlled temperature not more than 550C. Dried
    granules are screened via the appropriate mesh
    screen.

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Steps Involved in Pharmaceutical Tablet
Manufacturing
  • Tablet Compression
  • This step includes compression granules into flat
    or convex, oblong, round, or unique shaped,
    scored, or unscored tablets engraved with a
    recognized symbol and/ or code number using a
    tablet press.
  • Coating
  • Granules and tablets are coated if there is a
    need to mask the unpleasant taste/odor of some
    drug substance or increase the aesthetic look of
    uncoated tablets and modify the release or
    control the release drug substance from tablets.
    This is accomplished by enclosing or covering the
    primary tablet or granules with coating solutions.

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Packaging and Storing of Tablets
  • Before sending out tablets to the distributor,
    they are generally packaged using the latest
    packaging techniques and materials. The type of
    packaging material utilized is superior. We
    choose the material based on several factors,
    including
  • Compatibility of the material with the
    formulation.
  • The degree of protection required.
  • Presentation, especially for those pharma
    products which may be the subject of impulse
    buying
  • Customer convenience in terms of weight, size,
    method of opening or reclosing, legibility of
    printing, etc.
  • Filling Method and
  • Cost

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Types of Tablet Packaging
Our top-notch pharma product packaging provides
excellent environmental protection for each
tablet unit, coupled with an aesthetically
pleasing and productive appearance. At JoinHub
Pharma, pharmaceutical tablets are typically
packed using blister and strip packs and are kept
in low humidity and save from extreme
temperatures. Blister and strip packaging
additionally offer some degree of tamper
resistance to the dosage form.
Blister Packaging Tablets This is a universal
term for preformed plastic packaging for
pharmaceuticals tablets. The major element of the
blister pack is in the thermoformed plastic. It
has a fundamental tablet packaging that will
envelop the product and keep it in place. The
main components of the blister packs are the
cavity and the lidding.
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We will then cover it with secondary packaging
for grouping all primary packages in one place.
It further has an aluminum leading foil,
paperboard backing, or plastic seal. You may also
use a clamshell, a type of blister that folds
onto itself. We use the blister packages for
unit packaging of doses.
Bottle Packaging of Tablets We place the tablets
in a bottle which is the primary package. After
that, we cover the bottle with a lid which acts
as the secondary package. This type of tablet
packaging is used for very strong tablets that
cannot break easily. After packaging the tablets
in either the blister package or bottle package,
we place them in a tertiary package like boxes
for bulk handling.
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Let us proceed to the last section of this guide,
covering the quality control tests. For larger
quantities delivered to the pharmacist, plastic
or glass bottles, cartons, metal containers, or
paperboard drums are used along with polyethylene
liners, whenever required, to provide extra
protection from moisture. If cotton wool
stuffing is used under these circumstances, we
use external liners so that any moisture it
contains does not gain access to the tablets.
Tablets that are decomposed when exposed to
moisture are packaged with a desiccant packet.
Light-sensitive tablets are packaged in
light-resistant containers. With just a couple of
exemptions, tablets that are well stored will
remain stable for many years.
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Joinhub Pharma A Leading Pharmaceutical Tablet
Manufacturer
  • An ISO Certified Third-Party Pharmaceutical
    tablet manufacturing Company adheres to WHO, and
    GMP Guidelines have a Trusted name in providing
    Third-Party Manufacturing services for Tablets.
  • Being the Best Pharmaceutical Tablets
    Manufacturer in India, we offer to manufacture
    all Tablets segments such as analgesics,
    antibiotics, antiemetics, anti-infectives,
    anti-allergic, local anesthesia,
    anti-inflammatory, etc. We Manufacture tablets
    intending to be uniform in drug content and
    weight, chemically really stable and free of
    defects. Also, it uses the latest packaging
    technologies Flexible selection of more modern
    and venerable science.
  • We always focus on manufacturing pharma tablets
    that are effective and hard to resist several
    movements without breaking yet become an easy
    solution in dissolution.
  • Looking for the best pharmaceutical tablet
    manufacturer and supplier in Latin America, South
    Africa, and Middle East?

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  • Want quality pharmaceuticals tablets drug/
    medicines range? Look no further than JoinHub
    Pharma The top pharmaceuticals tablets
    manufacturer in India that brings total quality
    controls, Schedule M units, best packaging
    technique, skilled brains, and quick distribution
    chains, all under one roof.
  • Reach out to our pharma experts today by just
    dropping an email at info_at_joinhubpharma.com

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