Chronic Myelogenous Leukemia

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DR PAWAN KUMAR SINGH
Dr Pawan Kumar Singh has the experience of
performing more than 500 bone marrow transplants
(including Autologous /Allogenic /Haplo /MDU )for
both malignant and non-malignant disorders.
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CHRONIC MYELOID LEUKEMIA
Chronic Myeloid Leukemia (CML) is a type of
cancer that affects the blood and bone marrow. It
is a form of leukaemia characterized by the
uncontrolled growth of myeloid cells, which are
responsible for producing red blood cells,
platelets, and white blood cells. This content
aims to provide a comprehensive overview of CML,
including its causes, symptoms, diagnosis, and
treatment options
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CAUSES SYMPTOMS
CML is often associated with a genetic
abnormality known as the Philadelphia chromosome.
This chromosome results from a translocation
between chromosomes 9 and 22, leading to the
formation of a fusion gene called BCR-ABL. The
presence of this gene is a hallmark of CML and
plays a crucial role in the development of the
disease.
SYMPTOMS
The symptoms of CML can vary from person to
person, and some individuals may not exhibit any
symptoms during the early stages. Common symptoms
include fatigue, weakness, weight loss, night
sweats, and an enlarged spleen or liver. As the
disease progresses, CML may lead to an increased
risk of infections, easy bruising or bleeding,
and bone pain.
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DIAGNOSIS STAGING
CML is generally classified into three phases
chronic phase, accelerated phase, and blast
phase. Most individuals are diagnosed in the
chronic phase, which is characterized by the slow
progression of the disease. If left untreated,
CML may progress to the accelerated phase and
eventually to the blast phase, which is more
aggressive and resembles acute leukemia.
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TREATMENT PROGNOSIS
With advancements in treatment, the prognosis for
individuals with CML has significantly improved.
Many patients can achieve long-term remission and
lead normal, productive lives with proper medical
management. Regular monitoring and follow-up with
healthcare professionals are essential to ensure
the effectiveness of the chosen treatment plan.
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CONCLUSION
Chronic Myeloid Leukemia is a complex and
challenging disease, but advancements in medical
research and treatment options have provided hope
for those affected. Early diagnosis, combined
with targeted therapies, has transformed CML into
a manageable condition for many individuals.
Ongoing research continues to enhance our
understanding of the disease and improve
treatment outcomes, offering optimism for the
future.
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