EFFECT OF MAGNESIUM SULPHATE IN THE TREATMENT OF ASTHMA

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EFFECT OF MAGNESIUM SULPHATE IN THE TREATMENT OF
ASTHMA
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Inhaled magnesium sulfate in the treatment of
acute asthma Powell C, Dwan K, Milan SJ, Beasley
R, Hughes R, Knopp-Sihota JA, Rowe BH Cochrane
Database of Systematic Reviews 2012, Issue 12.
Art. No. CD003898. DOI 10.1002/14651858.CD003898
.pub5.
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Comparison 3 MgSO4 and SABA and ipratropium
versus placebo (saline) and SABA and ipratropium,
Outcome 1 Pulmonary function (FEV1).
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The review found that using inhaled magnesium
sulfate combined with a beta-2-agonist (with or
without ipratropium) for an acute asthma attack
does not significantly improve pulmonary function
(and therefore does not help people to breathe
more freely) overall, but there may be
improvement in adults with particularly severe
asthma attacks, which merits further study. The
evidence, however, that the addition of nebulised
magnesium sulfate is helpful with regard to
clinically important outcomes, such as reducing
hospital admissions, is not proven by the
clinical trials included in the review.
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Magnesium sulfate for treating exacerbations of
acute asthma in the emergency department Rowe
BH, Bretzlaff J, Bourdon C, Bota G, Blitz S,
Camargo CA Cochrane Database of Systematic
Reviews 2000, Issue 1. Art. No. CD001490.
DOI10.1002/14651858.CD001490.
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Comparison 1 Intravenous MgSO4 vs placebo,
Outcome 2 Pulmonary function testing.
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Comparison 2 Intravenous MgSO4 vs Placebo
(Severe Asthma subgroup), Outcome 1 Pulmonary
function testing.
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The review of trials found that intravenous
magnesium sulfate in addition to bronchodilators
seems to be safe and beneficial for people with
severe asthma attacks, or those for whom
bronchodilators are not working. Hence
intravenous Magnesium sulphate and not inhaled
magnesium sulphate is recommended in the
treatment of acute asthma.
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