(PDF) Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 2002nd Edition Ipad

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2
Description
In the pharmaceutical industry, the incorporation
of the disciplines of pharma- kinetics,
pharmacodynamics, and drug metabolism (PK/PD/DM)
into various drug development processes has been
recognized to be extremely important for approp-
ate compound selection and optimization. During
discovery phases, the identifi- tion of the
critical PK/PD/DM issues of new compounds plays
an essential role in understanding their
pharmacological profiles and structure-activity
relationships. Owing to recent progress in
analytical chemistry, a large number of compounds
can be screened for their PK/PD/DM properties
within a relatively short period of time. During
development phases as well, the toxicology and
clinical study designs and trials of a
compound should be based on a thorough
understanding of its PK/PD/DM properties. During
my time as an industrial scientist, I realized
that a reference work designed for practical
industrial applications of PK/PD/DM could be a
very valuable tool for researchers not only in
the pharmacokinetics and drug metabolism
departments, but also for other discovery and
development groups in pharmaceutical companies.
This book is designed specifically for
industrial scientists, laboratory assistants, and
managers who are involved in PK/PD/DM-related
areas. It consists of thirteen chapters, each of
which deals with a particular PK/PD/DM issue and
its industrial applications. Chapters 3 and 12 in
particular address recent topics on higher
throughput in vivo exposure screening and the
prediction of pharmacokinetics in
humans, respectively. Chapter 8 covers essential
information on drug metabolism for industrial
scientists.
3
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Description
In the pharmaceutical industry, the incorporation
of the disciplines of pharma- kinetics,
pharmacodynamics, and drug metabolism (PK/PD/DM)
into various drug development processes has been
recognized to be extremely important for approp-
ate compound selection and optimization.
During discovery phases, the identifi- tion of
the critical PK/PD/DM issues of new compounds
plays an essential role in understanding their
pharmacological profiles and structure-activity
relationships. Owing to recent progress in
analytical chemistry, a large number of compounds
can be screened for their PK/PD/DM properties
within a relatively short period of time. During
development phases as well, the toxicology
and clinical study designs and trials of a
compound should be based on a thorough
understanding of its PK/PD/DM properties. During
my time as an industrial scientist, I realized
that a reference work designed for practical
industrial applications of PK/PD/DM could be a
very valuable tool for researchers not only
in the pharmacokinetics and drug metabolism
departments, but also for other discovery and
development groups in pharmaceutical companies.
This book is designed specifically for industrial
scientists, laboratory assistants, and managers
who are involved in PK/PD/DM-related areas. It
consists of thirteen chapters, each of which
deals with a particular PK/PD/DM issue and its
industrial applications. Chapters 3 and 12 in
particular address recent topics on higher
throughput in vivo exposure screening and
the prediction of pharmacokinetics in humans,
respectively. Chapter 8 covers essential
information on drug metabolism for industrial
scientists.
6
(PDF) Handbook of Essential Pharmacokinetics, Phar
macodynamics and Drug Metabolism for
Industrial Scientists 2002nd Edition Ipad