Title: (PDF) Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development Android
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2Description
A comprehensive review of contemporary antisense
oligonucleotides drugs and therapeutic
principles, methods, applications, and
researchnbspOlionucleotide-based drugs, in
particular antisense oligonucleotides, are part
of a growing number of pharmaceutical and
biotech programs progressing to treat a wide
range of indications including cancer, cardiovascu
lar, neurodegenerative, neuromuscular, and
respiratory diseases, as well as other severe and
rare diseases. Reviewing fundamentals
and offering guidelines for drug discovery and
development, this book is a practical guide
covering all key aspects of this increasingly
popular area of pharmacology and biotech and
pharma research, from the basic science behind
antisense oligonucleotides chemistry, toxicology,
manufacturing, to safety assessments, the design
of therapeutic protocols, to clinical experience.A
ntisense oligonucleotides are single strands of
DNA or RNA that are complementary to a chosen
sequence. While the idea of antisense oligonucleot
ides to target single genes dates back to the
1970's, most advances have taken place in recent
years. The increasing number of antisense
oligonucleotide programs in clinical development
is a testament to the progress and understanding
of pharmacologic, pharmacokinetic,
and toxicologic properties as well as improvement
in the delivery of oligonucleotides. This
valuable book reviews the fundamentals
of oligonucleotides, with a focus on antisense
oligonucleotide drugs, and reports on the latest
research underway worldwide.8226nbspnbspnbsp
Helps readers understand antisense molecules and
their targets, biochemistry, and toxicity
mechanisms, roles in disease, and applications
for safety and therapeutics8226nbspnbspnbsp
Examines the principles, practices, and tools for
scientists in both pre-clinical and clinical
settings and how to apply them to antisense
oligonucleotides8226nbspnbspnbsp
Provides guidelines for scientists in drug design
and discovery to help improve efficiency,
assessment, and the success of drug
candidates8226nbspnbspnbsp Includes
interdisciplinary perspectives, from academia,
industry, regulatory and from the fields of
pharmacology, toxicology, biology, and medicinal
chemistryOligonucleotide-Based Drugs
and Therapeutics belongs on the reference shelves
of chemists, pharmaceutical scientists, chemical
biologists, toxicologists and other scientists
working in the pharmaceutical and biotechnology
industries. It will also be a valuable resource
for regulatory specialists and safety assessment
professionals and an important reference for
academic researchers and post-graduates interested
in therapeutics, antisense therapy, and
oligonucleotides.
3BESTSELLER
4(PDF) Oligonucleotide-Based Drugs
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Clinical Considerations for Development Android
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5Description
A comprehensive review of contemporary antisense
oligonucleotides drugs and therapeutic
principles, methods, applications, and
researchnbspOlionucleotide-based drugs, in
particular antisense oligonucleotides, are part
of a growing number of pharmaceutical and biotech
programs progressing to treat a wide range of
indications including cancer, cardiovascular,
neurodegenerative, neuromuscular, and respiratory
diseases, as well as other severe and rare
diseases. Reviewing fundamentals and offering
guidelines for drug discovery and development,
this book is a practical guide covering all
key aspects of this increasingly popular area of
pharmacology and biotech and pharma research,
from the basic science behind antisense
oligonucleotides chemistry, toxicology,
manufacturing, to safety assessments, the design
of therapeutic protocols, to clinical
experience.Antisense oligonucleotides are single
strands of DNA or RNA that are complementary to a
chosen sequence. While the idea of antisense
oligonucleotides to target single genes dates
back to the 1970's, most advances have
taken place in recent years. The increasing
number of antisense oligonucleotide programs in
clinical development is a testament to the
progress and understanding of pharmacologic,
pharmacokinetic, and toxicologic properties as
well as improvement in the delivery of
oligonucleotides. This valuable book reviews the
fundamentals of oligonucleotides, with a focus on
antisense oligonucleotide drugs, and reports on
the latest research underway worldwide.8226nbsp
nbspnbsp Helps readers understand antisense
molecules and their targets, biochemistry, and
toxicity mechanisms, roles in disease,
and applications for safety and
therapeutics8226nbspnbspnbsp Examines the
principles, practices, and tools for scientists
in both pre-clinical and clinical settings and
how to apply them to antisense oligonucleotides8
226nbspnbspnbsp Provides guidelines for
scientists in drug design and discovery to help
improve efficiency, assessment, and the success
of drug candidates8226nbspnbspnbsp Includes
interdisciplinary perspectives, from academia,
industry, regulatory and from the fields
of pharmacology, toxicology, biology, and
medicinal chemistryOligonucleotide-Based Drugs
and Therapeutics belongs on the reference shelves
of chemists, pharmaceutical scientists,
chemical biologists, toxicologists and other
scientists working in the pharmaceutical and
biotechnology industries. It will also be a
valuable resource for regulatory specialists and
safety assessment professionals and an important
reference for academic researchers and
post-graduates interested in therapeutics,
antisense therapy, and oligonucleotides.
6(PDF) Oligonucleotide-Based Drugs and
Therapeutics Preclinical and Clinical
Considerations for Development Android