[PDF] Rabies (Developments in Veterinary Virology, 7) Free

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Description
Rabies is an ancient disease and a fearsome one.
Although it may not have the economic or public
health importance of some other infectious
diseases, few are so well known or carry the same
emotional impact. Mainly transmitted by the bite
of an enraged animal, and with practically no
hope for recovery among those afflicted, it has
provided the substance of stories and
legends throughout the ages. The pioneering work
of many 19th century workers, culminating in the
development of the first rabies vaccines by Louis
Pasteur, provided the ground work for the modern
era in the study of rabies. Since then, and
particularly in the last quarter century,
considerable advances have been made in our
knowledge of the nature of the infectious agent,
its mode of transmission and pathogenetic
mechanisms. Yet even today, much remains to be
learned about the disease. For example, although
effective vaccines exist for humans and other
animals, there is still no known practical cure
once the neurological disease symptoms develop.
Markers of virulence have been mapped at the
molecular level, but it is yet unclear as to how
rabies virus actually exerts its pathological
effects.
3
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Description
Rabies is an ancient disease and a fearsome one.
Although it may not have the economic or
public health importance of some other infectious
diseases, few are so well known or carry the same
emotional impact. Mainly transmitted by the bite
of an enraged animal, and with practically no
hope for recovery among those afflicted, it has
provided the substance of stories and legends
throughout the ages. The pioneering work of many
19th century workers, culminating in the
development of the first rabies vaccines by Louis
Pasteur, provided the ground work for the modern
era in the study of rabies. Since then, and
particularly in the last quarter century,
considerable advances have been made in
our knowledge of the nature of the infectious
agent, its mode of transmission and pathogenetic
mechanisms. Yet even today, much remains to be
learned about the disease. For example, although
effective vaccines exist for humans and other
animals, there is still no known practical cure
once the neurological disease symptoms develop.
Markers of virulence have been mapped at the
molecular level, but it is yet unclear as to how
rabies virus actually exerts its pathological
effects.
6
PDF Rabies (Developments in Veterinary
Virology, 7) Free