Bioavailability Reboot

1
(No Transcript)
2
Maxicuma is clinically studied to deliver J72
foLds
more free curcumin in the Human Pharmacokinetic
study
compared to standard curcumin 957
(micronized) Published in the Journal of Current
Research of Complementary and Alternative
Medicine 7 191. Get access of the full published
version hei e In an open-label, non-randomized,
two-perioct, single dose, twD-group crossover
study with the total duration of 21 days
(including T4 days washout period), on healthy
adults, under fasting conditions, Maxicuma
exhibitecl (in comparison with standard curcumin
3
Maxicuma vis Micronized
O
Curcumin
Free Curcumin
More Free Curcumin
Free DMC
Free BDMC
Maxicuma
Micronized Curcumin 95
Higher Total AUCt
4
The free curcumin component in blood plasma is
responsible for biological action. Research
suggests that the level of efficacy is best
determined by the levels of unmetabofized free
curcumin in the ingredient. Inactive
Constituents Excreted rapidly, producing little
or no biological activity.
5
Curcumin Bioavailability - The GOLD Standards

• Most of the new generation curcumin ingredients
  claim higher bioavailability. as tney reflect the
  total curcuminoid levels without specifying the
  metabolites and free curcumin funmetabolized
  major bioactive) in their product, misleading the
  formulators with tall claims.
• The right way of measuring and reporting every
  curcuminoid compound in its free form, as well as
  its respective metabolite, is the pold standard
  of measuring the bioavailability of turmeric
  ingredients, as performed in studies
  investigating Maxicuma.

6
Bibtiography

• MarieL CaLderón-Oliver et at., 2022. The Role of
  Microencapsulation in Food Application.
• Sidney J. Stohsel af., 2019. The fallacy of
  enzymatic hydrolysis for the determination of
  bioactive curcumin in plasma samples as an
  indication of bioavailability A comparative
  study.
• Kednapa Thavorn et aL., 2023. A systematic review
  of the efficacy and safety of turmeric in the
  treatment of digestive disorders.

Get in touch