Acquired immunity

1
Acquired immunity
HMI
CMI
2
Humoral Mediated Immunity (HMI)
3
B cell
B cell receptor BCR surface immunoglobulin
???????????
4
B cell receptor BCR surface immunoglobulin
2
3
1
4
5
Specificity
6
Specificity Protection
phagocytes
7
Antibodies Protection Specificity
In vivo
8
Cell-Mediated Immunity (CMI)
9
CMI
T lymphocytes
Other cells
10
?????????????????????? 2 ????
1. Exogenous antigen
2. Endogenous antigen
11
Exogenous antigen
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???????? ??????
12
Endogenous antigen
??????????? ??????????????????????????
13
Virus
Target cell
14
Target cell
15
Target cell
16
Target cell
Host cell
Transcription Translation
Viral protein
17
Exogenous antigen
Microbes Proteins
?????????????????????????? Cell-mediated immunity
18
(No Transcript)
19
Antigen Presenting cells
Monocytes Peripheral blood Macrophages
Tissues Dendritic cells Lymphoid tissues
Langerhans cells Epidermis B-cells Lymphoid
tissue, Blood
20
Exogenous antigen
Antigen presenting cells Monocytes/Macrophages Den
dritic cells Langerhans cells B-cells
21
6
1
5
4
2
3
Invariant chain(Ii)
Class II MHC
22
T lymphocytes
T cell receptor
TCR
CD4 lymphocytes
CD8 lymphocytes
CD8 cell
CD4 cell
23
CD4 lymphocytes
T cell receptor
TCR
???????????
24
6
1
5
4
2
3
Invariant chain(Ii)
25
TCR-MHC interaction
T cells
T cells
T cells
TCR
TCR
TCR
Y
X
X
MHC
MHC
MHC
APC
APC
APC
Recognition
No Recognition
26
T cells
T cell activation
TCR
1. Antigen specific
2. MHC restriction
MHC class II
1
2
APC
27
CD4-MHC class II interaction
Antigen presenting cell
Antigen presenting cell
Antigen presenting cell
CD4
CD4
MHC class II
CD4
TCR
T cell
T cell
T cell
28
Invariant chain(Ii)
29
Accessory molecules
T cell
APC
30
Lymphokines
31
Innate immunity
HMI
CMI
APC
32
T and B cell co-operation
Antigen
Proliferation
Antibodies
B cells
Differentiation
Thymus independent antigen (T independent
antigen)
Thymus dependent antigen (T dependent antigen)
33
Thymus dependent antigen
34
Innate immunity
HMI
CMI
APC